Immunology of age-related macular degeneration

被引：526

作者：

Ambati, Jayakrishna ^{[1
,2
]}

Atkinson, John P. ^{[3
]}

Gelfand, Bradley D. ^{[1
,4
,5
]}

机构：

[1] Univ Kentucky, Dept Ophthalmol & Visual Sci, Lexington, KY 40506 USA

[2] Univ Kentucky, Dept Physiol, Lexington, KY 40506 USA

[3] Washington Univ, Dept Med, Div Rheumatol, St Louis, MO 63110 USA

[4] Univ Kentucky, Dept Biomed Engn, Lexington, KY 40506 USA

[5] Univ Kentucky, Dept Microbiol Immunol & Mol Genet, Lexington, KY 40506 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2013年 / 13卷 / 06期

基金：

美国国家卫生研究院;

关键词：

COMPLEMENT FACTOR-H; RETINAL-PIGMENT EPITHELIUM; ENDOTHELIAL GROWTH-FACTOR; INTRAVITREAL TRIAMCINOLONE ACETONIDE; GENOME-WIDE ASSOCIATION; C-REACTIVE PROTEIN; CHOROIDAL NEOVASCULARIZATION; GEOGRAPHIC ATROPHY; BRUCHS MEMBRANE; OXIDATIVE STRESS;

D O I：

10.1038/nri3459

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Age-related macular degeneration (AMD) is a leading cause of blindness in aged individuals. Recent advances have highlighted the essential role of immune processes in the development, progression and treatment of AMD. In this Review we discuss recent discoveries related to the immunological aspects of AMD pathogenesis. We outline the diverse immune cell types, inflammatory activators and pathways that are involved. Finally, we discuss the future of inflammation-directed therapeutics to treat AMD in the growing aged population.

引用

页码：438 / 451

页数：14

共 160 条

[1]

INTRAVITREAL BEVACIZUMAB VERSUS COMBINED INTRAVITREAL BEVACIZUMAB AND TRIAMCINOLONE FOR NEOVASCULAR AGE-RELATED MACULAR DEGENERATION Six-Month Results of a Randomized Clinical Trial [J].

Ahmadieh, Hamid ;

Taei, Ramin ;

Riazi-Esfahani, Mohammad ;

Piri, Niloufar ;

Homayouni, Mansour ;

Daftarian, Narsis ;

Yaseri, Mehdi .

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 2011, 31 (09) :1819-1826

[2]

An animal model of age-related macular degeneration in senescent Ccl-2-or Ccr-2-deficient mice [J].

Ambati, J ;

Anand, A ;

Fernandez, S ;

Sakurai, E ;

Lynn, BC ;

Kuziel, WA ;

Rollins, BJ ;

Ambati, BK .

NATURE MEDICINE, 2003, 9 (11) :1390-1397

[3]

Ambati, J ;

Ambati, BK ;

Yoo, SH ;

Ianchulev, S ;

Adamis, AP .

SURVEY OF OPHTHALMOLOGY, 2003, 48 (03) :257-293

[4]

Mechanisms of Age-Related Macular Degeneration [J].

Ambati, Jayakrishna ;

Fowler, Benjamin J. .

NEURON, 2012, 75 (01) :26-39

[5]

Perspective - A role for local inflammation in the formation of drusen in the aging eye [J].

Anderson, DH ;

Mullins, RF ;

Hageman, GS ;

Johnson, LV .

AMERICAN JOURNAL OF OPHTHALMOLOGY, 2002, 134 (03) :411-431

[6]

The pivotal role of the complement system in aging and age-related macular degeneration: Hypothesis re-visited [J].

Anderson, Don H. ;

Radeke, Monte J. ;

Gallo, Natasha B. ;

Chapin, Ethan A. ;

Johnson, Patrick T. ;

Curletti, Christy R. ;

Hancox, Lisa S. ;

Hu, Jane ;

Ebright, Jessica N. ;

Malek, Goldis ;

Hauser, Michael A. ;

Rickman, Catherine Bowes ;

Bok, Dean ;

Hageman, Gregory S. ;

Johnson, Lincoln V. .

PROGRESS IN RETINAL AND EYE RESEARCH, 2010, 29 (02) :95-112

[7]

[Anonymous], 2010, GLOB EC COST VIS IMP

[8]

Macrophages inhibit neovascularization in a murine model of age-related macular degeneration [J].

Apte, Rajendra S. ;

Richter, Jennifer ;

Herndon, John ;

Ferguson, Thomas A. .

PLOS MEDICINE, 2006, 3 (08) :1371-1381

[9]

Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population [J].

Arakawa, Satoshi ;

Takahashi, Atsushi ;

Ashikawa, Kyota ;

Hosono, Naoya ;

Aoi, Tomomi ;

Yasuda, Miho ;

Oshima, Yuji ;

Yoshida, Shigeo ;

Enaida, Hiroshi ;

Tsuchihashi, Takashi ;

Mori, Keisuke ;

Honda, Shigeru ;

Negi, Akira ;

Arakawa, Akira ;

Kadonosono, Kazuaki ;

Kiyohara, Yutaka ;

Kamatani, Naoyuki ;

Nakamura, Yusuke ;

Ishibashi, Tatsuro ;

Kubo, Michiaki .

NATURE GENETICS, 2011, 43 (10) :1001-U114

[10]

BAUDOUIN C, 1992, JPN J OPHTHALMOL, V36, P443

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