Neuroscience - Alzheimer's disease: Genotypes, phenotype, and treatments

被引:788
作者
Selkoe, DJ
机构
[1] Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston
关键词
D O I
10.1126/science.275.5300.630
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
[No abstract available]
引用
收藏
页码:630 / 631
页数:2
相关论文
共 33 条
  • [1] RELEASE OF EXCESS AMYLOID BETA-PROTEIN FROM A MUTANT AMYLOID BETA-PROTEIN PRECURSOR
    CAI, XD
    GOLDE, TE
    YOUNKIN, SG
    [J]. SCIENCE, 1993, 259 (5094) : 514 - 516
  • [2] EXCESSIVE PRODUCTION OF AMYLOID BETA-PROTEIN BY PERIPHERAL CELLS OF SYMPTOMATIC AND PRESYMPTOMATIC PATIENTS CARRYING THE SWEDISH FAMILIAL ALZHEIMER-DISEASE MUTATION
    CITRON, M
    VIGOPELFREY, C
    TEPLOW, DB
    MILLER, C
    SCHENK, D
    JOHNSTON, J
    WINBLAD, B
    VENIZELOS, N
    LANNFELT, L
    SELKOE, DJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (25) : 11993 - 11997
  • [3] Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice
    Citron, M
    Westaway, D
    Xia, WM
    Carlson, G
    Diehl, T
    Levesque, G
    JohnsonWood, K
    Lee, M
    Seubert, P
    Davis, A
    Kholodenko, D
    Motter, R
    Sherrington, R
    Perry, B
    Yao, H
    Strome, R
    Lieberburg, I
    Rommens, J
    Kim, S
    Schenk, D
    Fraser, P
    Hyslop, PS
    Selkoe, DJ
    [J]. NATURE MEDICINE, 1997, 3 (01) : 67 - 72
  • [4] MUTATION OF THE BETA-AMYLOID PRECURSOR PROTEIN IN FAMILIAL ALZHEIMERS-DISEASE INCREASES BETA-PROTEIN PRODUCTION
    CITRON, M
    OLTERSDORF, T
    HAASS, C
    MCCONLOGUE, L
    HUNG, AY
    SEUBERT, P
    VIGOPELFREY, C
    LIEBERBURG, I
    SELKOE, DJ
    [J]. NATURE, 1992, 360 (6405) : 672 - 674
  • [5] GENE DOSE OF APOLIPOPROTEIN-E TYPE-4 ALLELE AND THE RISK OF ALZHEIMERS-DISEASE IN LATE-ONSET FAMILIES
    CORDER, EH
    SAUNDERS, AM
    STRITTMATTER, WJ
    SCHMECHEL, DE
    GASKELL, PC
    SMALL, GW
    ROSES, AD
    HAINES, JL
    PERICAKVANCE, MA
    [J]. SCIENCE, 1993, 261 (5123) : 921 - 923
  • [6] Increased amyloid-beta 42(43) in brains of mice expressing mutant presenilin 1
    Duff, K
    Eckman, C
    Zehr, C
    Yu, X
    Prada, CM
    Pereztur, J
    Hutton, M
    Buee, L
    Harigaya, Y
    Yager, D
    Morgan, D
    Gordon, MN
    Holcomb, L
    Refolo, L
    Zenk, B
    Hardy, J
    Younkin, S
    [J]. NATURE, 1996, 383 (6602) : 710 - 713
  • [7] ALZHEIMER-TYPE NEUROPATHOLOGY IN TRANSGENIC MICE OVEREXPRESSING V717F BETA-AMYLOID PRECURSOR PROTEIN
    GAMES, D
    ADAMS, D
    ALESSANDRINI, R
    BARBOUR, R
    BERTHELETTE, P
    BLACKWELL, C
    CARR, T
    CLEMENS, J
    DONALDSON, T
    GILLESPIE, F
    GUIDO, T
    HAGOPIAN, S
    JOHNSONWOOD, K
    KHAN, K
    LEE, M
    LEIBOWITZ, P
    LIEBERBURG, I
    LITTLE, S
    MASLIAH, E
    MCCONLOGUE, L
    MONTOYAZAVALA, M
    MUCKE, L
    PAGANINI, L
    PENNIMAN, E
    POWER, M
    SCHENK, D
    SEUBERT, P
    SNYDER, B
    SORIANO, F
    TAN, H
    VITALE, J
    WADSWORTH, S
    WOLOZIN, B
    ZHAO, J
    [J]. NATURE, 1995, 373 (6514) : 523 - 527
  • [8] GAMES D, 1995, SOC NEUR ABSTR, V21, P258
  • [9] A beta-peptide length and apolipoprotein E genotype in Alzheimer's disease
    Gearing, M
    Mori, H
    Mirra, SS
    [J]. ANNALS OF NEUROLOGY, 1996, 39 (03) : 395 - 399
  • [10] APOLIPOPROTEIN-E EPSILON-4 AND CEREBRAL-HEMORRHAGE ASSOCIATED WITH AMYLOID ANGIOPATHY
    GREENBERG, SM
    REBECK, GW
    VONSATTEL, JPG
    GOMEZISLA, T
    HYMAN, BT
    [J]. ANNALS OF NEUROLOGY, 1995, 38 (02) : 254 - 259