Biological and psychological markers of stress in humans: Focus on the Trier Social Stress Test

被引：528

作者：

Allen, Andrew P. ^{[1
,2
]}

Kennedy, Paul J. ^{[1
,2
]}

Cryan, John F. ^{[1
,3
]}

Dinan, Timothy G. ^{[1
,2
]}

Clarke, Gerard ^{[1
,2
]}

机构：

[1] Natl Univ Ireland Univ Coll Cork, Alimentary Pharmabiot Ctr, Cork, Ireland

[2] Natl Univ Ireland Univ Coll Cork, Dept Psychiat, Cork, Ireland

[3] Natl Univ Ireland Univ Coll Cork, Dept Anat & Neurosci, Cork, Ireland

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2014年 / 38卷

基金：

爱尔兰科学基金会;

关键词：

Stress; Cortisol; ACTH; Serotonin; HPA axis; Sympathetic-adrenal-medullary system; Brain-gut axis; Heart rate; Immune system; Genetics; ACUTE PSYCHOSOCIAL STRESS; PITUITARY-ADRENAL AXIS; SALIVARY ALPHA-AMYLASE; DEXAMETHASONE-SUPPRESSION TEST; SYMPATHETIC-NERVOUS-SYSTEM; IRRITABLE-BOWEL-SYNDROME; ACUTE MENTAL STRESS; TRANSPORTER PROMOTER POLYMORPHISM; INFLAMMATORY CYTOKINE PRODUCTION; CORTICOTROPIN-RELEASING-FACTOR;

D O I：

10.1016/j.neubiorev.2013.11.005

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Validated biological and psychological markers of acute stress in humans are an important tool in translational research. The Trier Social Stress Test (TSST), involving public interview and mental arithmetic performance, is among the most popular methods of inducing acute stress in experimental settings, and reliably increases hypothalamic-pituitary-adrenal axis activation. However, although much research has focused on HPA axis activity, the TSST also affects the sympathetic-adrenal-medullary system, the immune system, cardiovascular outputs, gastric function and cognition. We critically assess the utility of different biological and psychological markers, with guidance for future research, and discuss factors which can moderate TSST effects. We outline the effects of the TSST in stress-related disorders, and if these responses can be abrogated by pharmacological and psychological treatments. Modified TSST protocols are discussed, and the TSST is compared to alternative methods of inducing acute stress. Our analysis suggests that multiple readouts are necessary to derive maximum information; this strategy will enhance our understanding of the psychobiology of stress and provide the means to assess novel therapeutic agents. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：94 / 124

页数：31

共 441 条

[1] Comparison of the low dose short synacthen test (1 μg), the conventional dose short synacthen test (250 μg), and the insulin tolerance test for assessment of the hypothalamo-pituitary-adrenal axis in patients with pituitary disease [J].