Ovarian Cancer and Body Size: Individual Participant Meta-Analysis Including 25,157 Women with Ovarian Cancer from 47 Epidemiological Studies

被引：125

作者：

Beral, V. ^{[1
]}

Hermon, C. ^{[1
]}

Peto, R. ^{[5
,6
]}

Reeves, G. ^{[1
]}

Brinton, L. ^{[32
]}

Marchbanks, P. ^{[8
]}

Negri, E. ^{[27
]}

Ness, R.

Peeters, P. H. M. ^{[48
]}

Vessey, M. ^{[16
]}

Calle, E. E. ^{[2
]}

Gapstur, S. M. ^{[2
]}

Patel, A. V. ^{[2
]}

Dal Maso, L. ^{[3
]}

Talamini, R. ^{[3
]}

Chetrit, A. ^{[4
]}

Hirsh-Yechezkel, G. ^{[4
]}

Lubin, F. ^{[4
]}

Sadetzki, S. ^{[4
]}

Allen, N. ^{[1
]}

Bull, D. ^{[1
]}

Callaghan, K. ^{[1
]}

Crossley, B. ^{[1
]}

Gaitskell, K. ^{[1
]}

Goodill, A. ^{[1
]}

Green, J. ^{[1
]}

Key, T. ^{[1
]}

Moser, K. ^{[1
]}

Collins, R. ^{[5
,6
]}

Doll, R. ^{[5
,6
]}

Gonzalez, C. A. ^{[7
]}

Lee, N. ^{[8
]}

Ory, H. W. ^{[8
]}

Peterson, H. B. ^{[8
]}

Wingo, P. A. ^{[8
]}

Martin, N. ^{[9
]}

Pardthaisong, T. ^{[9
]}

Silpisornkosol, S. ^{[9
]}

Theetranont, C. ^{[9
]}

Boosiri, B. ^{[10
]}

Chutivongse, S. ^{[10
]}

Jimakorn, P. ^{[10
]}

Virutamasen, P. ^{[10
]}

Wongsrichanalai, C. ^{[10
]}

Tjonneland, A. ^{[11
]}

Titus-Ernstoff, L. ^{[12
]}

Byers, T. ^{[13
]}

Rohan, T. ^{[14
]}

Mosgaard, B. J. ^{[15
]}

Yeates, D. ^{[16
]}

机构：

[1] Canc Epidemiol Unit, Oxford, England

[2] Amer Canc Soc, Atlanta, GA 30329 USA

[3] Aviano Canc Ctr, Pordenone, Italy

[4] Gertner Inst, Canc & Radiat Epidemiol Unit, Tel Hashomer, Israel

[5] Canc Res UK MRC BHF Clin Trial Serv Unit, Oxford, England

[6] Epidemiol Studies Unit, Oxford, England

[7] Catalan Inst Oncol, Barcelona, Spain

[8] Ctr Dis Control & Prevent, Atlanta, GA USA

[9] Chiang Mai Univ, Chiang Mai 50000, Thailand

[10] Chulalongkorn Univ, Bangkok, Thailand

[11] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[12] Dartmouth Coll, Hitchcock Med Ctr, Dartmouth Med Sch, Hanover, NH 03756 USA

[13] Colorado Sch Publ Hlth, Dept Epidemiol, Denver, CO USA

[14] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA

[15] Herlev Univ Hosp, Dept Obstet & Gynaecol, Copenhagen, Denmark

[16] Dept Publ Hlth, Oxford, England

[17] SUNY Buffalo, Dept Social & Prevent Med, Buffalo, NY 14260 USA

[18] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[19] Univ Minnesota, Sch Publ Hlth, Div Epidemiol, Minneapolis, MN 55455 USA

[20] Univ Washington, Fred Hutchinson Canc Res Ctr, Seattle, WA 98195 USA

[21] Univ London Imperial Coll Sci Technol & Med, London, England

[22] Paris S Univ, UMRS 1018, Inst Cancerol Gustave Roussy, Villejuif, France

[23] INSERM, U1018, Villejuif, France

[24] Harvard Univ, Sch Med, Brigham & Womens Hosp, Cambridge, MA 02138 USA

[25] Harvard Univ, Sch Med, Channing Lab Nurses Hlth Study, Cambridge, MA 02138 USA

[26] Int Agcy Res Canc, F-69372 Lyon, France

[27] Univ Milan, Ist Ric Farmacol Mario Negri, Milan, Italy

[28] Karolinska Inst, Stockholm, Sweden

[29] Maastricht Univ, Maastricht, Netherlands

[30] Mahidol Univ, Bangkok 10700, Thailand

[31] Canc Res & Prevent Inst, Mol & Nutr Epidemiol Unit, Florence, Italy

[32] NCI, Bethesda, MD 20892 USA

[33] Norwegian Inst Publ Hlth, Oslo, Norway

[34] Queensland Inst Med Res, Brisbane, Qld 4006, Australia

[35] Univ Queensland, Brisbane, Qld 4072, Australia

[36] Roswell Pk Canc Inst, Buffalo, NY 14263 USA

[37] Royal Coll Gen Practitioners Oral Contracept Stud, London, England

[38] Curtin Univ Technol, Sch Publ Hlth, Perth, WA, Australia

[39] Univ Texas Houston, Sch Publ Hlth, Houston, TX USA

[40] Univ Massachusetts, Sch Publ Hlth & Hlth Sci, Boston, MA 02125 USA

[41] Boston Univ, Slone Epidemiol Ctr, Boston, MA 02215 USA

[42] Stanford Univ, Stanford, CA 94305 USA

[43] Univ Athens, Sch Med, GR-11527 Athens, Greece

[44] Univ Chile, Santiago, Chile

[45] Univ Hawaii, Honolulu, HI 96822 USA

[46] Univ Hosp, Lund, Sweden

[47] Univ Penn, Philadelphia, PA 19104 USA

[48] Univ Med Ctr Utrecht, Utrecht, Netherlands

[49] Univ So Calif, Los Angeles, CA USA

[50] Univ Toronto, Toronto, ON, Canada

来源：

PLOS MEDICINE | 2012年 / 9卷 / 04期

关键词：

REQUIRING PROLONGED OBSERVATION; ORAL-CONTRACEPTIVE USE; EPITHELIAL OVARIAN; MASS INDEX; ANTHROPOMETRIC MEASURES; PROSPECTIVE COHORT; HORMONAL FACTORS; RISK-FACTORS; LIFE-STYLE; HEIGHT;

D O I：

10.1371/journal.pmed.1001200

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Only about half the studies that have collected information on the relevance of women's height and body mass index to their risk of developing ovarian cancer have published their results, and findings are inconsistent. Here, we bring together the worldwide evidence, published and unpublished, and describe these relationships. Methods and Findings: Individual data on 25,157 women with ovarian cancer and 81,311 women without ovarian cancer from 47 epidemiological studies were collected, checked, and analysed centrally. Adjusted relative risks of ovarian cancer were calculated, by height and by body mass index. Ovarian cancer risk increased significantly with height and with body mass index, except in studies using hospital controls. For other study designs, the relative risk of ovarian cancer per 5 cm increase in height was 1.07 (95% confidence interval [CI], 1.05-1.09; p<0.001); this relationship did not vary significantly by women's age, year of birth, education, age at menarche, parity, menopausal status, smoking, alcohol consumption, having had a hysterectomy, having first degree relatives with ovarian or breast cancer, use of oral contraceptives, or use of menopausal hormone therapy. For body mass index, there was significant heterogeneity (p<0.001) in the findings between ever-users and never-users of menopausal hormone therapy, but not by the 11 other factors listed above. The relative risk for ovarian cancer per 5 kg/m(2) increase in body mass index was 1.10 (95% CI, 1.07-1.13; p<0.001) in never-users and 0.95 (95% CI, 0.92-0.99; p = 0.02) in ever-users of hormone therapy. Conclusions: Ovarian cancer is associated with height and, among never-users of hormone therapy, with body mass index. In high-income countries, both height and body mass index have been increasing in birth cohorts now developing the disease. If all other relevant factors had remained constant, then these increases in height and weight would be associated with a 3% increase in ovarian cancer incidence per decade.

引用

页数：12

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