Intermittent blood flow in solid tumours - an under-appreciated source of 'drug resistance'

被引:45
作者
Durand, RE [1 ]
机构
[1] British Columbia Canc Res Ctr, Dept Med Biophys, Vancouver, BC V5Z 1L3, Canada
基金
加拿大健康研究院;
关键词
solid tumours; blood flow; chemotherapy; resistance;
D O I
10.1023/A:1013181107707
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
As the search for improved anti-cancer drugs continues, new paradigms concerning the reasons for clinical failures in common human solid tumours are also evolving. Classical drug resistance is now perhaps less often invoked to explain lack of treatment efficacy than are newer concepts, including 'contact resistance', 'tumour heterogeneity', 'regrowth resistance', and 'physiological barriers' to drug delivery. This commentary will explore the resistance of solid tumours to chemotherapy from yet another, largely ignored perspective: that of tumour-specific fluctuations in blood flow. Transient decreases in blood flow have significant implications for delivery of chemotherapeutic agents, cellular responsiveness to those agents, and the regrowth potential of the surviving tumour cells.
引用
收藏
页码:57 / 61
页数:5
相关论文
共 51 条
[1]  
ACKER H, 1984, SPHEROIDS CANC RES
[2]   Comparison between the comet assay and the oxygen microelectrode for measurement of tumor hypoxia [J].
Aquino-Parsons, C ;
Luo, CM ;
Vikse, CM ;
Olive, PL .
RADIOTHERAPY AND ONCOLOGY, 1999, 51 (02) :179-185
[3]   LACK OF GENERAL CORRELATION BETWEEN INTERSTITIAL FLUID PRESSURE AND OXYGEN PARTIAL-PRESSURE IN SOLID TUMORS [J].
BOUCHER, Y ;
LEE, I ;
JAIN, RK .
MICROVASCULAR RESEARCH, 1995, 50 (02) :175-182
[4]   PRETREATMENT OXYGENATION PROFILES OF HUMAN SOFT-TISSUE SARCOMAS [J].
BRIZEL, DM ;
ROSNER, GL ;
HARRELSON, J ;
PROSNITZ, LR ;
DEWHIRST, MW .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1994, 30 (03) :635-642
[5]   TUMOR HYPOXIA - THE PICTURE HAS CHANGED IN THE 1990S [J].
BROWN, JM ;
GIACCIA, AJ .
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1994, 65 (01) :95-102
[6]   ATP synthesis during low-flow ischemia - Influence of increased glycolytic substrate [J].
Cave, AC ;
Ingwall, JS ;
Friedrich, J ;
Liao, RL ;
Saupe, KW ;
Apstein, CS ;
Eberli, FR .
CIRCULATION, 2000, 101 (17) :2090-2096
[7]  
CHAPLIN DJ, 1987, CANCER RES, V47, P597
[8]   ACUTE-HYPOXIA IN TUMORS - IMPLICATIONS FOR MODIFIERS OF RADIATION EFFECTS [J].
CHAPLIN, DJ ;
DURAND, RE ;
OLIVE, PL .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1986, 12 (08) :1279-1282
[10]  
Cowan DSM, 1996, BRIT J CANCER, V74, pS28