A testicular germ cell-associated serine-threonine kinase, MAK, is dispensable for sperm formation

被引：37

作者：

Shinkai, Y

Satoh, H

Takeda, N

Fukuda, M

Chiba, E

Kato, T

Kuramochi, T

Araki, Y

机构：

[1] Kyoto Univ, Inst Virus Res, Dept Cell Biol, Kyoto 6068507, Japan

[2] Nippon Roche Res Ctr, Dept Oncol, Kamakura, Kanagawa 2470063, Japan

[3] Yamagata Univ, Sch Med, Dept Immunol & Parasitol, Yamagata 9909585, Japan

[4] Cent Inst Expt Anim, Kawasaki, Kanagawa 2160001, Japan

来源：

MOLECULAR AND CELLULAR BIOLOGY | 2002年 / 22卷 / 10期

关键词：

D O I：

10.1128/MCB.22.10.3276-3280.2002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A member of the mitogen-activated protein kinase superfamily, MAK, has been proposed to have an important role in spermatogenesis, since Mak gene expression is highly restricted to testicular germ cells. To assess the biological function of MAK, we have established MAK-deficient (Mak(-/-)) mice. Mak(-/-) mice developed normally, and no gross abnormalities were observed. Spermatogenesis of the Mak(-/-) mice was also intact, and most of the mice were fertile. However, Mak(-/-) male-derived litter sizes and their sperm motility in vitro were mildly reduced. These data show that function of MAK is not essential for spermatogenesis and male fertility.

引用

页码：3276 / 3280

页数：5

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