A protein domain-based interactome network for C-elegans early embryogenesis

被引：162

作者：

Boxem, Mike ^{[1
,2
,3
,4
]}

Maliga, Zoltan ^{[5
]}

Klitgord, Niels ^{[1
,2
,3
]}

Li, Na ^{[1
,2
,3
]}

Lemmens, Irma ^{[6
,7
]}

Mana, Miyeko ^{[9
]}

de Lichtervelde, Lorenzo ^{[1
,2
,3
]}

Mul, Joram D. ^{[1
,2
,3
]}

van de Peut, Diederik ^{[1
,2
,3
]}

Devos, Maxime ^{[1
,2
,3
]}

Simonis, Nicolas ^{[1
,2
,3
]}

Yildirim, Muhammed A. ^{[1
,2
,3
]}

Cokol, Murat ^{[8
]}

Kao, Huey-Ling ^{[9
]}

de Smet, Anne-Sophie ^{[5
,6
,7
]}

Wang, Haidong ^{[10
]}

Schlaitz, Anne-Lore

Hao, Tong ^{[1
,2
,3
]}

Milstein, Stuart ^{[1
,2
,3
]}

Fan, Changyu ^{[1
,2
,3
]}

Tipsword, Mike ^{[5
]}

Drew, Kevin ^{[9
]}

Galli, Matilde ^{[11
]}

Rhrissorrakrai, Kahn ^{[9
]}

Drechsel, David ^{[5
]}

Koller, Daphne ^{[10
]}

Roth, Frederick P. ^{[8
]}

Iakoucheva, Lilia M. ^{[12
]}

Dunker, A. Keith ^{[13
]}

Bonneau, Richard ^{[9
]}

Gunsalus, Kristin C. ^{[9
]}

Hill, David E. ^{[1
,2
,3
]}

Piano, Fabio ^{[9
]}

Tavernier, Jan ^{[6
,7
]}

van den Heuvel, Sander ^{[11
]}

Hyman, Anthony A. ^{[5
]}

Vidal, Marc ^{[1
,2
,3
]}

机构：

[1] Harvard Univ, Sch Med, CCSB, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

[4] Massachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA

[5] Max Planck Inst Mol Cell Biol & Genet, D-01307 Dresden, Germany

[6] Univ Ghent VIB, Dept Med Prot Res, B-9000 Ghent, Belgium

[7] Univ Ghent, Fac Med & Hlth Sci, Dept Biochem, B-9000 Ghent, Belgium

[8] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

[9] NYU, Ctr Genom & Syst Biol, Dept Biol, New York, NY 10003 USA

[10] Stanford Univ, Dept Comp Sci, Stanford, CA 94305 USA

[11] Univ Utrecht, Fac Sci, Div Dev Biol, NL-3584 CH Utrecht, Netherlands

[12] Rockefeller Univ, Lab Stat Genet, New York, NY 10065 USA

[13] Indiana Univ, Sch Med & Informat, Ctr Computat Biol & Bioinformat, Indianapolis, IN 46202 USA

来源：

CELL | 2008年 / 134卷 / 03期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1016/j.cell.2008.07.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Many protein-protein interactions are mediated through independently folding modular domains. Proteome-wide efforts to model protein-protein interaction or "interactome'' networks have largely ignored this modular organization of proteins. We developed an experimental strategy to efficiently identify interaction domains and generated a domain-based interactome network for proteins involved in C. elegans early-embryonic cell divisions. Minimal interacting regions were identified for over 200 proteins, providing important information on their domain organization. Furthermore, our approach increased the sensitivity of the two-hybrid system, resulting in amore complete interactome network. This interactome modeling strategy revealed insights into C. elegans centrosome function and is applicable to other biological processes in this and other organisms.

引用

页码：534 / 545

页数：12

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