Chronic rhinosinusitis and superantigens

被引：35

作者：

Seiberling, KA ^{[1
]}

Grammer, L ^{[1
]}

Kern, RC ^{[1
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Dept Otolaryngol Head & Neck Surg, Chicago, IL 60611 USA

来源：

OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA | 2005年 / 38卷 / 06期

关键词：

D O I：

10.1016/j.otc.2005.08.006

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

This article discusses the potential role of bacterial superantigens (SAgs) in chronic rhinosinusitis with nasal polyposis (CRS/NP). First, it briefly describes SAgs, focusing on how they interact with the immune system by binding to T-cell receptors (TCR) and major histocompatibility complex (MHC) class II molecules. Second, it discusses the role of SAgs in other chronic inflammatory diseases. Finally, it presents evidence for the role of SAgs in the pathogenesis and maintenance of CRS/NP focusing on current research and future considerations.

引用

页码：1215 / +

页数：23

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