Haloacetylated enol ethers .8. Reaction of beta-alkoxyvinyl trihalomethyl ketones with guanidine hydrochloride. Synthesis of 4-trihalomethyl-2-aminopyrimidines

被引：77

作者：

Zanatta, N

Cortelini, MDM

Carpes, MJS

Bonacorso, HG

Martins, MAP

机构：

[1] Departamento de Química, Universidade Federal de Santa Maria, 97.119-900-Santa Maria, RS

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1997年 / 34卷 / 02期

关键词：

D O I：

10.1002/jhet.5570340226

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this work the results of the reaction of beta-alkoxyvinyl trihalomethyl ketones 1, 2a-e, with guanidine hydrochloride are reported. Depending on the ketone 1 or 2 and the conditions under which the reactions were carried our 4-trihalomethyl-2-amino pyrimidines, beta-alkoxyvinyl carboxylic acids, or beta-acetal carboxylic esters were obtained.

引用

页码：509 / 513

页数：5

共 33 条

[1] ANALOGS OF TETRAHYDROFOLIC ACID .26. SYNTHESIS OF SOME 5-ARYL AND 5-ARALKYL PYRIMIDINE-6-CARBOXYLIC ACIDS AND THEIR EFFECT ON DIHYDROFOLIC REDUCTASE AND THYMIDYLATE SYNTHETASE [J].