The myasthenia gravis thymus: A rare source of human autoantibody-secreting plasma cells for testing potential therapeutics

被引：43

作者：

Hill, Marguerite E. ^{[3
]}

Shiono, Hiroyuki ^{[2
]}

Newsom-Davis, John ^{[1
]}

Willcox, Nick ^{[1
]}

机构：

[1] Univ Oxford, Weatherall Inst Mol Med, Neurosci Grp, Oxford OX3 9DS, England

[2] Osaka Police Hosp, Dept Gen Thorac Surg, Osaka 5430035, Japan

[3] Morriston Hosp, Dept Neurosci, Swansea SA6 6NL, W Glam, Wales

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2008年 / 201卷

关键词：

Plasma cells; Autoimmunity; Acetylcholine receptor; Autoantibody; Myasthenia gravis; Thymus; Germinal center;

D O I：

10.1016/j.jneuroim.2008.06.027

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

In early-onset myasthenia gravis(EOMG), the thymus is colonized by lymph node-like infiltrates including T cell areas and germinal centers. Our Group(1) showed (1978) spontaneous anti-acetylcholine receptor (AChR) autoantibody production by EOMG thymic cells. Especially after enzymic dispersal, these are enriched in plasma cells that are evidently autonomous, long-lived, terminally differentiated and radio-resistant. Radiolabeled AChR is highly sensitive both for localizing them in situ and detecting their ongoing antibody production in culture at limiting cell numbers. Thus EOMG thymi are a readily available Source of specific autoimmune human plasma Cells Suitable for studying their biology and testing new therapies. (C) 2008 Elsevier B.V. All rights reserved.

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页数：7

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