Antibiotic Resistance of Helicobacter Pylori Isolated in the Southeast Coastal Region of China

被引：198

作者：

Su, Peng ^{[1
]}

Li, Youming ^{[2
]}

Li, Hongzhang ^{[3
]}

Zhang, Jiakun ^{[4
]}

Lin, Lang ^{[5
]}

Wang, Qunying ^{[6
]}

Guo, Feng ^{[7
]}

Ji, Zizhong ^{[8
]}

Mao, Jibo ^{[9
]}

Tang, Wuheng ^{[10
]}

Shi, Zhengchao ^{[11
]}

Shao, Wei ^{[12
]}

Mao, Junliang ^{[13
]}

Zhu, Xinjian ^{[14
]}

Zhang, Xiaofeng ^{[15
]}

Tong, Yuefeng ^{[16
]}

Tu, Huimin ^{[17
]}

Jiang, Mizu ^{[18
]}

Wang, Zhiyong ^{[19
]}

Jin, Fengzhe ^{[20
]}

Yang, Ningmin ^{[21
]}

Zhang, Jianzhong ^{[1
]}

机构：

[1] Chinese Ctr Dis Control & Prevent, Natl Inst Communicable Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing 102206, Peoples R China

[2] Zhejiang Univ, Coll Med, Affiliated Hosp 1, Hangzhou 310003, Zhejiang, Peoples R China

[3] Sanmen Peoples Hosp, Taizhou, Peoples R China

[4] First Peoples Hosp Pingyang, Wenzhou, Peoples R China

[5] First Peoples Hosp Cangnan, Wenzhou, Peoples R China

[6] Jinhua Municipal Cent Hosp, Jinhua, Peoples R China

[7] First Peoples Hosp Xiaoshan Dist, Hangzhou, Zhejiang, Peoples R China

[8] First Hosp Jiaxing, Jiaxing, Peoples R China

[9] Zhoushan Hosp, Zhoushan, Peoples R China

[10] Zhoushan Women & Childrens Hosp, Zhoushan, Peoples R China

[11] Ruian Peoples Hosp, Wenzhou, Peoples R China

[12] Peoples Hosp Putuo Dist, Zhoushan, Peoples R China

[13] First Peoples Hosp Wenling, Taizhou, Peoples R China

[14] Shangyu Peoples Hosp, Shangyu, Peoples R China

[15] Hangzhou First Peoples Hosp, Hangzhou, Zhejiang, Peoples R China

[16] First Peoples Hosp Yongkang, Jinhua, Peoples R China

[17] Suzhou Univ, Wuxi Hosp 4, Wuxi, Peoples R China

[18] Zhejiang Univ, Sch Med, Childrens Hosp, Hangzhou 310003, Zhejiang, Peoples R China

[19] Hangzhou Normal Univ, Affiliated Hosp, Hangzhou, Zhejiang, Peoples R China

[20] Ruian City TCM Hosp, Wenzhou, Peoples R China

[21] Zhiyuan Med Inspect Inst CO LTD, Hangzhou, Zhejiang, Peoples R China

来源：

HELICOBACTER | 2013年 / 18卷 / 04期

关键词：

Helicobacter pylori; antibiotic resistance; clarithromycin; metronidazole; levofloxacin; amoxicillin; CLARITHROMYCIN RESISTANCE; METRONIDAZOLE RESISTANCE; LEVOFLOXACIN; ERADICATION; STRAINS; MANAGEMENT; THERAPY; TRIPLE; EPIDEMIOLOGY; GUIDELINES;

D O I：

10.1111/hel.12046

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Background The resistance of Helicobacter pylori (H.pylori) to antibiotics is increasing worldwide, lowering its efficacy in current eradication therapies. This study evaluated H.pylori resistance to antibiotics in the southeast coastal region of China and suggests appropriate alternatives. Materials and Methods Seventeen thousand seven hundred and thirty one H.pylori strains were collected from eight areas of two provinces in coastal southeast China from 2010 to 2012. The resistance of these strains to six antibiotics was tested using the agar dilution method. Results The resistance rates to clarithromycin, metronidazole, levofloxacin, amoxicillin, gentamicin and furazolidone were 21.5, 95.4, 20.6, 0.1, 0.1 and 0.1%, respectively. Double, triple and quadruple antibacterial resistant percentages were 25.5, 7.5 and 0.1%, respectively. A positive association between the resistance to levofloxacin and to clarithromycin was found, but there was a negative correlation in the resistances to levofloxacin and to metronidazole. Conclusions The prevalence of H.pylori resistance to clarithromycin, metronidazole, levofloxacin and multiple antibiotics in coastal southeast China is high. Choice of therapy should be individualized based on a susceptibility test in this region of the country.

引用

页码：274 / 279

页数：6

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