Functional insulin-like growth factor-1/insulin-like growth factor-1 receptor-mediated circuit in human and murine thymic epithelial cells

被引：30

作者：

Coelho, VDM

Villa-Verde, DMS

Farias-De-Oliveira, DA

de Brito, JM

Dardenne, M

Savino, W

机构：

[1] Univ Paris 05, CNRS UMR 8603, Hop Necker Enfants Malad, F-75015 Paris, France

[2] Inst Oswaldo Cruz, Oswaldo Cruz Fdn, Dept Immunol, Lab Thymus Res, BR-20001 Rio De Janeiro, Brazil

[3] NIA, Immunol Lab, Baltimore, MD 21224 USA

[4] Univ Fed Rio de Janeiro, Inst Biomed Sci, Dept Histol & Embryol, Rio De Janeiro, Brazil

来源：

NEUROENDOCRINOLOGY | 2002年 / 75卷 / 02期

关键词：

insulin-like growth factors; insulin-like growth factor receptors; growth hormone; thymus; thymocytes; extracellular matrix; neuroimmune interactions; lymphocytes; mouse; human;

D O I：

10.1159/000048230

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Interactions between thymocytes and thymic epithelial cell (TEC) can be modulated by growth hormone via insulin-like growth factor-1 (IGF-1). In this study, we showed IGF-1 and IGF-1 receptor mRNA expression by human and murine TEC and thymocytes. Functionally, IGF-1 stimulates extracellular matrix production by human TEC. Moreover, pretreatment of murine TEC with IGF-1 increases their adhesion to thymocytes. Interestingly, we observed an increase in the frequency of CD4-CD8-CD90+ T cells which adhered to pretreated TEC, supporting the concept that IGF-1 may also act indirectly on intrathymic T cell differentiation and migration through the thymic epithelium. Copyright (C) 2002 S. KargerAG.

引用

页码：139 / 150

页数：12

共 58 条

[1] MURINE MACROPHAGES EXPRESS ABUNDANT INSULIN-LIKE GROWTH FACTOR-I CLASS-I EA AND EB TRANSCRIPTS [J].