Indomethacin in the management of elevated intracranial pressure: A review

被引：35

作者：

Harrigan, MR

Tuteja, S

Neudeck, BL

机构：

[1] UNIV MICHIGAN, MED CTR, DEPT SURG, NEUROSURG SECT, ANN ARBOR, MI 48109 USA

[2] UNIV MICHIGAN, COLL PHARM, ANN ARBOR, MI 48109 USA

来源：

JOURNAL OF NEUROTRAUMA | 1997年 / 14卷 / 09期

关键词：

cerebral blood flow; cerebral edema; head injury; indomethacin; intracranial pressure; CEREBRAL BLOOD-FLOW; SEVERE HEAD-INJURY; CARBON-DIOXIDE; PROSTAGLANDIN SYNTHESIS; CEREBROSPINAL-FLUID; CONSCIOUS RABBITS; MILD HYPERTHERMIA; COMATOSE PATIENTS; ARACHIDONIC-ACID; BLEEDING-TIME;

D O I：

10.1089/neu.1997.14.637

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Elevated intracranial pressure occurs frequently in patients with severe head injury, A number of studies in recent years suggest that indomethacin may be useful in the management of elevated intracranial pressure, Indomethacin acts primarily by reducing cerebral blood flow and decreasing cerebral edema following head injury. This review summarizes the basic and clinical studies of the effects of indomethacin on cerebral blood flow, brain edema, and intracranial pressure, The pharmacology of indomethacin, and issues for future investigation in the use of indomethacin in severe head injury, are discussed.

引用

页码：637 / 650

页数：14

共 106 条

[1] REGIONAL AND SPECIES-DIFFERENCES IN ENDOGENOUS PROSTAGLANDIN BIOSYNTHESIS BY BRAIN HOMOGENATES [J].