Hypoxia-inducible-factor-1 in trauma and critical care

被引：23

作者：

Bogdanovski, Dorian A. ^{[1
]}

DiFazio, Louis T. ^{[1
]}

Bogdanovski, Anastasia K. ^{[2
]}

Csoka, Balazs ^{[3
]}

Jordan, Garrett B. ^{[1
]}

Paul, Elina R. ^{[1
]}

Antonioli, Luca ^{[4
]}

Pilip, Stefanie A. ^{[1
]}

Nemeth, Zoltan H. ^{[1
,3
]}

机构：

[1] Morehouse Sch Med, Dept Surg, Atlanta, GA 30310 USA

[2] Rutgers New Jersey Med Sch, Newark, NJ USA

[3] Rutgers New Jersey Med Sch, Dept Surg, Newark, NJ USA

[4] Univ Pisa, Dept Clin & Expt Med, Pisa, Italy

来源：

JOURNAL OF CRITICAL CARE | 2017年 / 42卷

关键词：

HIF-1; Hypoxia; Inflammation; Sepsis; Ischemia; HYPOXIA-INDUCIBLE FACTOR; ACUTE LUNG INJURY; FACTOR; 1-ALPHA; FACTOR-I; HIF-1-ALPHA; VALIDATION; ACTIVATION; EXPRESSION; INDUCTION; APOPTOSIS;

D O I：

10.1016/j.jcrc.2017.07.029

中图分类号：

R4 [临床医学];

学科分类号：

100218 [急诊医学];

摘要：

HIF-1 is a ubiquitous signaling molecule constantly expressed by the body, but is degraded during normoxic conditions. In hypoxic conditions, it persists and is active. Hypoxia is often associated with trauma due to interrupted blood flow, inflammation or other reasons, causing HIF-1 to be active in signaling and recovery. In this review, the function of HIF-1 is examined, as well as its clinical significance with regard to trauma and critical care. Using this information, we then identify potential points of treatment and intervention. (c) 2017 Published by Elsevier Inc.

引用

页码：207 / 212

页数：6

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