Apolipoprotein E gender effects on cognitive performance in age-associated memory impairment

被引:23
作者
Bartrés-Faz, D [1 ]
Junqué, C [1 ]
Moral, P [1 ]
López-Alomar, A [1 ]
Sánchez-Aldeguer, J [1 ]
Clemente, IC [1 ]
机构
[1] Univ Barcelona, Dept Psychiat & Clin Psychobiol, Catalunya, Spain
关键词
D O I
10.1176/appi.neuropsych.14.1.80
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Among 100 individuals with age-associated memory impairment (AAMI), APOE E4 carriers performed worse oil memory. However, when subjects were considered by gender, this effect was only observed in females. APOE E4 may have a more robust cognitive influence on female than on male individuals with AAMI.
引用
收藏
页码:80 / 83
页数:4
相关论文
共 16 条
[1]   WOMEN, MYOCARDIAL-INFARCTION, AND DEMENTIA IN THE VERY OLD [J].
ARONSON, MK ;
OOI, WL ;
MORGENSTERN, H ;
HAFNER, A ;
MASUR, D ;
CRYSTAL, H ;
FRISHMAN, WH ;
FISHER, D ;
KATZMAN, R .
NEUROLOGY, 1990, 40 (07) :1102-1106
[2]   Apo E influences declarative and procedural learning in age-associated memory impairment [J].
Bartrés-Faz, D ;
Junqué, C ;
López, A ;
Valveny, N ;
Moral, P ;
Gálvez, E ;
López, T ;
Moya, A ;
Navarro, JL ;
Clemente, I .
NEUROREPORT, 1999, 10 (14) :2923-2927
[3]   Evidence for an interaction between apolipoprotein E genotype, gender, and Alzheimer disease [J].
Bretsky, PM ;
Buckwalter, JG ;
Seeman, TE ;
Miller, CA ;
Poirier, J ;
Schellenberg, GD ;
Finch, CE ;
Henderson, VW .
ALZHEIMER DISEASE & ASSOCIATED DISORDERS, 1999, 13 (04) :216-221
[4]   GENE DOSE OF APOLIPOPROTEIN-E TYPE-4 ALLELE AND THE RISK OF ALZHEIMERS-DISEASE IN LATE-ONSET FAMILIES [J].
CORDER, EH ;
SAUNDERS, AM ;
STRITTMATTER, WJ ;
SCHMECHEL, DE ;
GASKELL, PC ;
SMALL, GW ;
ROSES, AD ;
HAINES, JL ;
PERICAKVANCE, MA .
SCIENCE, 1993, 261 (5123) :921-923
[5]   Age-Associated Memory Impairment: Proposed Diagnostic Criteria and Measures of Clinical Change - Report of a National Institute of Mental Health Work Group [J].
Crook, Thomas ;
Bartus, Raymond T. ;
Ferris, Steven H. ;
Whitehouse, Peter ;
Cohen, Gene D. ;
Gershon, Samuel .
DEVELOPMENTAL NEUROPSYCHOLOGY, 1986, 2 (04) :261-276
[6]   Treatment outcome of tacrine therapy depends on apolipoprotein genotype and gender of the subjects with Alzheimer's disease [J].
Farlow, MR ;
Lahiri, DK ;
Poirier, J ;
Davignon, J ;
Schneider, L ;
Hui, SL .
NEUROLOGY, 1998, 50 (03) :669-677
[7]   Clinical and pathological correlates of apolipoprotein E epsilon 4 in Alzheimer's disease [J].
GomezIsla, T ;
West, HL ;
Rebeck, GW ;
Harr, SD ;
Growdon, JH ;
Locascio, JJ ;
Perls, TT ;
Lipsitz, LA ;
Hyman, BT .
ANNALS OF NEUROLOGY, 1996, 39 (01) :62-70
[8]  
HANNINEN T, 1995, J AM GERIATR SOC, V43, P1017
[9]   Apolipoprotein E and cognitive change in an elderly population [J].
Hyman, BT ;
GomezIsla, T ;
Briggs, M ;
Chung, H ;
Nichols, S ;
Kohout, F ;
Wallace, R .
ANNALS OF NEUROLOGY, 1996, 40 (01) :55-66
[10]   Rates and risk factors for dementia and Alzheimer's disease - Results from EURODEM pooled analyses [J].
Launer, LJ ;
Andersen, K ;
Dewey, ME ;
Letenneur, L ;
Ott, A ;
Amaducci, LA ;
Brayne, C ;
Copeland, JRM ;
Dartigues, JF ;
Kragh-Sorensen, P ;
Lobo, A ;
Martinez-Lage, JM ;
Stijnen, T ;
Hofman, A .
NEUROLOGY, 1999, 52 (01) :78-84