Bacterial toxins as tools for mucosal vaccination

被引：23

作者：

Mrsny, RJ

Daugherty, AL

McKee, ML

FitzGerald, DJ

机构：

[1] Cardiff Univ, Welsh Sch Pharm, Ctr Drug Delivery Biol, Cardiff CF10 3XF, S Glam, Wales

[2] NCI, Div Basic Sci, Lab Mol Biol, Biotherapy Sect NIH, Bethesda, MD 20892 USA

来源：

DRUG DISCOVERY TODAY | 2002年 / 7卷 / 04期

关键词：

D O I：

10.1016/S1359-6446(01)02139-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Several studies have demonstrated that the biological properties of secreted bacterial toxins could be harnessed for the induction of mucosal and systemic immunity following application at epithelial surfaces. Although the properties and potential application of several of these toxins will be discussed in this review, special focus will be placed on Pseudomonas aeruginosa exotoxin A (PE). A non-toxic form of PE (ntPE) into which antigenic epitopes can be integrated appears to be a particularly promising vaccination tool, which is able to cross the polarized epithelia of the gastrointestinal, respiratory and reproductive tracts and selectively target macrophages and dendritic cells.

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页码：247 / 258

页数：12

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