Modulation of 6-hydroxydopamine oxidation by various proteins

被引：20

作者：

Padiglia, A

Medda, R

Lorrai, A

Biggio, G

Sanna, E

Floris, G

机构：

[1] UNIV CAGLIARI,INST CHIM BIOL,I-09125 CAGLIARI,ITALY

[2] UNIV CAGLIARI,DEPT EXPT BIOL,NEUROSCI SECT,I-09125 CAGLIARI,ITALY

来源：

BIOCHEMICAL PHARMACOLOGY | 1997年 / 53卷 / 08期

关键词：

6-hydroxydopamine; superoxide dismutase; catalase; DT-diaphorase; ceruloplasmin; peroxidase;

D O I：

10.1016/S0006-2952(96)00716-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The spontaneous autoxidation of the neurotoxin 6-hydroxydopamine proceeds by a free radical chain reaction involving the superoxide anion radical and produces the corresponding chromogen 6-hydroxydopamine quinone and hydrogen peroxide. The rate of this reaction is increased in the presence of ceruloplasmin and peroxidase, and reduced by superoxide dismutase, catalase, and DT-diaphorase. We report some explanations of why these proteins may increase or reduce the rate of autoxidation of 6-hydroxydopamine. (C) 1997 Elsevier Science Inc.

引用

页码：1065 / 1068

页数：4

共 32 条

[1] INTERACTIONS BETWEEN METALS, LIGANDS, AND OXYGEN IN THE AUTOXIDATION OF 6-HYDROXYDOPAMINE - MECHANISMS BY WHICH METAL CHELATION ENHANCES INHIBITION BY SUPEROXIDE-DISMUTASE [J].