Modern vitiligo genetics sheds new light on an ancient disease

被引：60

作者：

Spritz, Richard A. ^{[1
]}

机构：

[1] Univ Colorado, Sch Med, Human Med Genet & Genom Program, Aurora, CO 80045 USA

来源：

JOURNAL OF DERMATOLOGY | 2013年 / 40卷 / 05期

基金：

美国国家卫生研究院;

关键词：

autoimmune destruction; disease prevention; vitiligo; vitiligo genetics; vitiligo pathogenesis; GENOME-WIDE ASSOCIATION; WEST-INDIES ISLE; ABO BLOOD-GROUPS; GENERALIZED VITILIGO; SUSCEPTIBILITY LOCI; FUNCTIONAL POLYMORPHISMS; FAMILIAL AGGREGATION; AUTOIMMUNE-DISEASES; LINKAGE ANALYSIS; COMMON VARIANTS;

D O I：

10.1111/1346-8138.12147

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Vitiligo is a complex disorder in which autoimmune destruction of melanocytes results in white patches of skin and overlying hair. Over the past several years, extensive genetic studies have outlined a biological framework of vitiligo pathobiology that underscores its relationship to other autoimmune diseases. This biological framework offers insight into both vitiligo pathogenesis and perhaps avenues towards more effective approaches to treatment and even disease prevention.

引用

页码：310 / 318

页数：9

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