Leptin-induced signal transduction pathways

被引：261

作者：

Hegyi, K

Fülöp, K

Kovács, K

Tóth, S

Falus, A

机构：

[1] Semmelweis Univ, Dept Genet Cell & Immunobiol, H-1089 Budapest, Hungary

[2] Hungarian Acad Sci, Inst Expt Med, Lab Mol Neuroendocrinol, Budapest, Hungary

[3] Hungarian Acad Sci, Mol Immunol Res Grp, Budapest, Hungary

来源：

CELL BIOLOGY INTERNATIONAL | 2004年 / 28卷 / 03期

关键词：

leptin; receptor; signal transduction;

D O I：

10.1016/j.cellbi.2003.12.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Leptin is a multifunctional cytokine and hormone that primarily acts in the hypothalamus and plays a key role in the regulation of food intake and energy expenditure. In addition, it has direct effects on many cell types on the periphery. Leptin acts through its receptor, the product of the db gene, which has six isoforms. Only one of them (OB-Rb) has full signalling capabilities and is able to activate the Jak/STAT pathway, the major pathway used by leptin to exert its effects. However, some signalling events can be initiated by the short isoforms. Besides Jak/STAT, other pathways, such as MAPK and the 5'-AMP-activated protein kinase (AMPK) pathway, are also involved in leptin signalling. Leptin also interacts with insulin signalling. In this paper, we give an overview of the signal transduction mechanisms that are related to the actions of leptin. (C) 2004 Elsevier Ltd. All rights reserved.

引用

收藏

页码：159 / 169

页数：11

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