Chemistry, pharmacology, and clinical efficacy of the Chinese nootropic agent huperzine A

被引：134

作者：

Kozikowski, AP ^{[1
]}

Tückmantel, W ^{[1
]}

机构：

[1] Georgetown Univ, Inst Cognit & Computat Sci, Drug Discovery Program, Washington, DC 20007 USA

来源：

ACCOUNTS OF CHEMICAL RESEARCH | 1999年 / 32卷 / 08期

关键词：

D O I：

10.1021/ar9800892

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[No abstract available]

引用

页码：641 / 650

页数：10

共 61 条

[1] MECHANISM OF INHIBITION OF CHOLINESTERASES BY HUPERZINE-A [J].

ASHANI, Y ;

PEGGINS, JO ;

DOCTOR, BP .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 184 (02) :719-726

[2]

ASHANI Y, 1996 MED DEFENSE BIO, V1, P105

[3] Effects of metrifonate on cognitive decline in Alzheimer disease: A double-blind, placebo-controlled, 6-month study [J].

Becker, RE ;

Colliver, JA ;

Markwell, SJ ;

Moriearty, PL ;

Unni, LK ;

Vicari, S .

ALZHEIMER DISEASE & ASSOCIATED DISORDERS, 1998, 12 (01) :54-57

[4] Restoration of TEA-induced calcium responses in fibroblasts from Alzheimer's disease patients by a PKC activator [J].

Bhagavan, S ;

Ibarreta, D ;

Ma, DW ;

Kozikowski, AP ;

Etcheberrigaray, R .

NEUROBIOLOGY OF DISEASE, 1998, 5 (03) :177-187

[5] Alpha-2 macroglobulin is genetically associated with Alzheimer disease [J].

Blacker, D ;

Wilcox, MA ;

Laird, NM ;

Rodes, L ;

Horvath, SM ;

Go, RCP ;

Perry, R ;

Watson, B ;

Bassett, SS ;

McInnis, MG ;

Albert, MS ;

Hyman, BT ;

Tanzi, RE .

NATURE GENETICS, 1998, 19 (04) :357-360

[6] The neurobiology of Alzheimer's disease [J].

Brion, JP .

ACTA CLINICA BELGICA, 1996, 51 (02) :80-90

[7] A PALLADIUM-CATALYZED ROUTE TO HUPERZINE-A AND ITS ANALOGS AND THEIR ANTICHOLINESTERASE ACTIVITY [J].

CAMPIANI, G ;

SUN, LQ ;

KOZIKOWSKI, AP ;

AAGAARD, P ;

MCKINNEY, M .

JOURNAL OF ORGANIC CHEMISTRY, 1993, 58 (27) :7660-7669

[8] BRIDGED RING-SYSTEMS .16. SYNTHETIC APPROACH TO LYCOPODIUM ALKALOIDS [J].

COLVIN, EW ;

DOYLE, M ;

SHROOT, B ;

RAPHAEL, RA ;

MARTIN, J ;

PARKER, W .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1972, (06) :860-&

[9] Mechanisms of neuronal death in Alzheimer's disease [J].

Cotman, CW ;

Su, JH .

BRAIN PATHOLOGY, 1996, 6 (04) :493-506

[10] A PRACTICAL AND EFFICIENT METHOD FOR THE SYNTHESIS OF BETA-LACTONES [J].

DANHEISER, RL ;

NOWICK, JS .

JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (03) :1176-1185

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