Growth hormone response to the GABA(B) agonist baclofen in major depressive disorder

被引：21

作者：

Davis, LL ^{[1
]}

Trivedi, M ^{[1
]}

Choate, A ^{[1
]}

Kramer, GL ^{[1
]}

Petty, F ^{[1
]}

机构：

[1] UNIV TEXAS, SW MED CTR, DALLAS, TX 75216 USA

来源：

PSYCHONEUROENDOCRINOLOGY | 1997年 / 22卷 / 03期

关键词：

major depression; baclofen; growth hormone; neuroendocrine; GABA-B receptor; gamma-aminobutyric acid;

D O I：

10.1016/S0306-4530(96)00048-0

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Growth hormone (GH) response to the gamma-aminobutyric acid B receptor agonist, baclofen, was measured in 16 male patients with major depressive disorder and in 16 age-matched healthy male controls. No significant differences were found in the GH response to baclofen between the depressed patients and controls. On repeat testing, the GH response to baclofen showed significant retest reliability in both groups. There was no significant correlation between serum baclofen levels and the GH response to baclofen. Age significantly correlated with GH response, with older subjects having lower GH response to baclofen. These data do not suggest that a blunted GK response to baclofen represents a specific neuroendocrine feature of major depression.

引用

页码：129 / 140

页数：12

共 48 条

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