Hypoxia-inducible factor-1 and neuroglobin expression

被引：61

作者：

Haines, Bryan ^{[1
]}

Demaria, Marco ^{[1
]}

Mao, Xiao ^{[1
]}

Xie, Lin ^{[1
]}

Campisi, Judith ^{[1
]}

Jin, Kunlin ^{[1
,2
]}

Greenberg, David A. ^{[1
]}

机构：

[1] Buck Inst Res Aging, Novato, CA 94945 USA

[2] Univ N Texas, Dept Pharmacol & Neurosci, Ft Worth, TX 76107 USA

来源：

NEUROSCIENCE LETTERS | 2012年 / 514卷 / 02期

关键词：

Neuroglobin; Hypoxia; Hypoxia-inducible factor-1; Stroke; PROTECTS; BRAIN; CELLS;

D O I：

10.1016/j.neulet.2012.01.080

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neuroglobin (Ngb) is a hypoxia-inducible protein with cytoprotective effects in animal models of stroke, Alzheimer's disease, and related disorders, but the molecular mechanisms involved in its induction are unknown. We tested the hypothesis that hypoxia-inducible factor-1 (HIF-1) regulates Ngb levels, using shRNA-mediated knockdown and lentiviral vector-mediated overexpression of the HIF-1 alpha sub-unit, in cultured neural (HN33) cells. HIF-1 alpha knockdown decreased and HIF-1 alpha overexpression increased Ngb levels, consistent with a connection between HIF-1 and Ngb induction. These findings may have implications for understanding the hypoxia-response repertoire of neural cells and devising therapeutic strategies for neurologic disorders. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

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收藏

页码：137 / 140

页数：4

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