Immunosuppressive iridoids from the fruits of Gardenia jasminoides

被引：69

作者：

Chang, WL ^{[1
]}

Wang, HY

Shi, LS

Lai, JH

Lin, HC

机构：

[1] Natl Def Univ, Natl Def Med Ctr, Sch Pharm, Taipei 114, Taiwan

[2] Tri Serv Gen Hosp, Dept Med, Taipei 114, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2005年 / 68卷 / 11期

关键词：

D O I：

10.1021/np0580816

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

A new iridoid, gardaloside (1), and a new safranal-type monoterpene, jasminoside G (2), together with 10 known compounds including nine iridoids and a second safranal-type monoterpene, were isolated from the fruits of Gardenia jasminoides. The structures of 1 and 2 were established on the basis of spectroscopic evidence. Of these compounds, geniposide (3), 6 alpha-hydroxygeniposide (5), ixoroside (7), and shanzhiside (8) showed significant inhibition of IL-2 secretion by phorbol myristate acetate and anti-CD28 monoclonal antibody co-stimulated activation of human peripheral blood T cells.

引用

页码：1683 / 1685

页数：3

共 12 条

[1]

FERETOSIDE AND GARDENOSIDE FROM FERETIA-APODANTHERA - C-13-NMR SPECTRA IN IRIDOID SERIES [J].