Complete nucleotide sequence of the rhesus lymphocryptovirus: Genetic validation for an Epstein-Barr virus animal model

被引：103

作者：

Rivailler, P ^{[1
]}

Jiang, H ^{[1
]}

Cho, YG ^{[1
]}

Quink, C ^{[1
]}

Wang, F ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med, Boston, MA 02115 USA

来源：

JOURNAL OF VIROLOGY | 2002年 / 76卷 / 01期

关键词：

D O I：

10.1128/JVI.76.1.421-426.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We sequenced the rhesus lymphocryptovirus (LCV) genome in order to determine its genetic similarity to Epstein-Barr virus (EBV). The rhesus LCV encodes a repertoire identical to that of EBV, with 80 open reading frames, including cellular interleukin-10, bcl-2, and colony-stimulating factor 1 receptor homologues and an equivalent set of viral glycoproteins. The highly conserved rhesus LCV gene repertoire provides a unique animal model for the study of EBV pathogenesis.

引用

页码：421 / 426

页数：6

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