Apoptosis and other immune biomarkers predict influenza vaccine responsiveness

被引：150

作者：

Furman, David ^{[1
]}

Jojic, Vladimir ^{[2
]}

Kidd, Brian ^{[3
]}

Shen-Orr, Shai ^{[4
]}

Price, Jordan ^{[1
]}

Jarrell, Justin ^{[5
]}

Tse, Tiffany ^{[3
]}

Huang, Huang ^{[1
]}

Lund, Peder ^{[1
]}

Maecker, Holden T. ^{[3
]}

Utz, Paul J. ^{[3
,5
]}

Dekker, Cornelia L. ^{[3
,6
]}

Koller, Daphne ^{[2
]}

Davis, Mark M. ^{[1
,3
,7
]}

机构：

[1] Stanford Univ, Sch Med, Dept Microbiol & Immunol, Palo Alto, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Comp Sci, Palo Alto, CA 94305 USA

[3] Stanford Univ, Sch Med, Inst Immun Transplantat & Infect, Palo Alto, CA 94305 USA

[4] Technion Israel Inst Technol, Fac Med, Dept Immunol, Haifa, Israel

[5] Stanford Univ, Sch Med, Dept Med, Div Rheumatol & Immunol, Palo Alto, CA 94305 USA

[6] Stanford Univ, Sch Med, Div Infect Dis, Dept Pediat, Palo Alto, CA 94305 USA

[7] Howard Hughes Med Inst, Chevy Chase, MD USA

来源：

MOLECULAR SYSTEMS BIOLOGY | 2013年 / 9卷

基金：

美国国家卫生研究院;

关键词：

aging; apoptosis; influenza; systems immunology; vaccinology; PROINFLAMMATORY CYTOKINE PRODUCTION; YELLOW-FEVER VACCINE; AGE-RELATED DEFECTS; CD8(+) T-CELLS; GERMINAL CENTER; SEASONAL INFLUENZA; ANTIPROLIFERATIVE ACTIVITY; ELDERLY INDIVIDUALS; SYSTEMS BIOLOGY; TRANSGENIC MICE;

D O I：

10.1038/msb.2013.15

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Despite the importance of the immune system in many diseases, there are currently no objective benchmarks of immunological health. In an effort to identifying such markers, we used influenza vaccination in 30 young (20-30 years) and 59 older subjects (60 to >89 years) as models for strong and weak immune responses, respectively, and assayed their serological responses to influenza strains as well as a wide variety of other parameters, including gene expression, antibodies to hemagglutinin peptides, serum cytokines, cell subset phenotypes and in vitro cytokine stimulation. Using machine learning, we identified nine variables that predict the antibody response with 84% accuracy. Two of these variables are involved in apoptosis, which positively associated with the response to vaccination and was confirmed to be a contributor to vaccine responsiveness in mice. The identification of these biomarkers provides new insights into what immune features may be most important for immune health.

引用

页数：14

共 73 条

[1]

NEW LOOK AT STATISTICAL-MODEL IDENTIFICATION [J].