Determination of S-phenylmercapturic acid in urine as an indicator of exposure to benzene

被引:32
作者
Ghittori, S
Imbriani, M
Maestri, L
Capodaglio, E
Cavalleri, A [1 ]
机构
[1] Univ Pavia, Dipartimento Med Prevent Occupaz & Communita, Pavia, Italy
[2] IRCCS, Fdn Clin Lavoro, I-27100 Pavia, Italy
关键词
benzene; urinalysis; S-phenylmercapturic acid;
D O I
10.1016/S0378-4274(99)00106-X
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
S-phenylmercapturic acid (S-PMA) was measured in urine from 145 subjects exposed to low benzene concentrations in the air (C-I, benzene). The 8-h, time-weighted exposure intensity of individual workers was monitored by means of charcoal tubes and subsequent gas-chromatographic analysis after desorption with CS2. S-PMA excretion level in urine was determined by high-performance liquid chromatography with fluorescence detection. The following linear correlation was found between S-PMA concentrations in urine and benzene concentrations in the breathing zone: log(S-PMA, mu g/g creatinine) = 0.712 log (C-I-benzene, ppm) + 1.644 (n = 145, r = 0.74, P < 0.001). The geometric mean (GSD) of S-PMA concentrations in urine from 45 subjects occupationally not exposed to benzene but smoking more than 20 cigarettes/day was 7.8 mu g/g creatinine (2.11), the corresponding value among non-smokers being 1.0 mu g/g creatinine (2.18). It is concluded that the urinary level of S-PMA can be regarded as a useful indicator of exposure to benzene. (C) 1999 Published by Elsevier Science Ireland Ltd. AU rights reserved.
引用
收藏
页码:329 / 334
页数:6
相关论文
共 17 条
[1]  
*ACGIH, 1998, THRESH LIM VAL CHEM
[2]  
ASKOV M, 1988, BENZENE CARCINOGENIC, P113
[3]  
BOLT MH, 1994, MED LAV, V85, P37
[4]   BIOLOGICAL MONITORING OF EXPOSURE TO BENZENE - A COMPARISON BETWEEN S-PHENYLMERCAPTURIC ACID, TRANS,TRANS-MUCONIC ACID, AND PHENOL [J].
BOOGAARD, PJ ;
VANSITTERT, NJ .
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 1995, 52 (09) :611-620
[5]  
DRUMMOND L, 1988, BRIT J IND MED, V45, P256
[6]  
*DTSCH FORSCH, 1998, 32 VCH DTSCH FORSCH
[7]  
FISHBEIN L, 1988, IARC SCI PUBL, V85, P67
[8]   Biological monitoring of vehicle mechanics and other workers exposed to low concentrations of benzene [J].
Hotz, P ;
Carbonnelle, P ;
Haufroid, V ;
Tschopp, A ;
Buchet, JP ;
Lauwerys, R .
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH, 1997, 70 (01) :29-40
[9]   S-PHENYL-N-ACETYLCYSTEINE IN URINE OF RATS AND WORKERS AFTER EXPOSURE TO BENZENE [J].
JONGENEELEN, FJ ;
DIRVEN, HAAM ;
LEIJDEKKERS, CM ;
HENDERSON, PT ;
BROUNS, RME ;
HALM, K .
JOURNAL OF ANALYTICAL TOXICOLOGY, 1987, 11 (03) :100-104
[10]  
LAUWERYS R, 1993, IND CHEM EXPOSURE GU