Pharyngeal Electrical Stimulation for Dysphagia Associated with Multiple Sclerosis: A Pilot Study

被引：45

作者：

Restivo, Domenico A. ^{[1
]}

Casabona, Antonino ^{[2
]}

Centonze, Diego ^{[3
,4
]}

Marchese-Ragona, Rosario ^{[5
]}

Maimone, Davide ^{[1
]}

Pavone, Antonino ^{[1
]}

机构：

[1] Nuovo Garibaldi Hosp, Dept Neurol, I-95100 Catania, Italy

[2] Univ Catania, Dept Biomed Sci, Physiol Sect, Catania, Italy

[3] Univ Roma Tor Vergata, Dipartimento Neurosci, Clin Neurol, I-00133 Rome, Italy

[4] Fdn Santa Lucia, CERC, I-00143 Rome, Italy

[5] Univ Padua, ENT Dept, Padua, Italy

来源：

BRAIN STIMULATION | 2013年 / 6卷 / 03期

关键词：

Swallowing; Dysphagia; Multiple sclerosis; Pharyngeal electrical stimulation; Sensory pharyngeal stimulation; Videofluoroscopy; BOTULINUM TOXIN; MOTOR CORTEX; SOLITARY TRACT; PLASTICITY; MECHANISMS; RESPONSES; NUCLEUS; STROKE; LAMB;

D O I：

10.1016/j.brs.2012.09.001

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Objective: Treatment options for dysphagia associated with multiple sclerosis (MS) are currently limited. In this study we investigated whether intraluminal electrical pharyngeal stimulation facilitates swallowing recovery in dysphagic MS patients. Patients and methods: Twenty dysphagic MS patients were randomized to receive 5 Hz "real" pharyngeal stimulation (10 patients) for 10 min or "sham" pharyngeal stimulation for 10 min (10 patients). Patients were evaluated by videofluoroscopic, and electromyographic examinations, and by the Penetration/ Aspiration Scale (PAS) performed before (T-0) and immediately after the last session of 5 consecutive days of electrical pharyngeal stimulation (T-1), and then after two (T-2), and four (T-3) weeks of 5 consecutive days of pharyngeal electrical stimulation. Results: Patients who received "real" stimulation showed a significant improvement in all the swallowing outcome measures as compared with those receiving "sham" stimulation. Conclusions: No specific treatment for oro-pharyngeal dysphagia related to MS has been described to date. Our preliminary findings suggest a potential benefit of intraluminal electrical pharyngeal stimulation for the treatment of dysphagia caused by MS. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：418 / 423

页数：6

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