Genetic association between SORL1 polymorphisms and Alzheimer's disease in a Japanese population

被引：36

作者：

Shibata, Nobuto ^{[1
]}

Ohnuma, Tohru

Baba, Hajime

Higashi, Shinji

Nishioka, Kenya ^{[2
]}

Arai, Heii

机构：

[1] Juntendo Univ, Sch Med, Dept Psychiat, Bunkyo Ku, Tokyo 1138421, Japan

[2] Juntendo Univ, Sch Med, Dept Neurol, Tokyo 1138421, Japan

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2008年 / 26卷 / 02期

关键词：

Alzheimer's disease; polymorphism; sortilin-related receptor 1; apolipoprotein E;

D O I：

10.1159/000149821

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Background/Aims: It has recently been shown that the neuronal sortilin-related receptor (SORL1) plays an important role in the pathogenesis of Alzheimer's disease (AD). Methods: To investigate whether variations around the SORL1 gene are associated with AD, 7 single-nucleotide polymorphisms (SNPs) were genotyped using TaqMan (R) technology with 180 AD patients and 130 age-matched controls. Results: Our results confirmed the strong linkage disequilibrium among the 7 SNPs studied. However, our study failed to detect any association between the SNPs and AD. We could not confirm any synergetic interaction between the SNPs and apolipoprotein E in our AD patients either. Conclusion: Further genetic studies are needed to clarify the relationship between the SORL1 gene and AD. Copyright (C) 2008 S. Karger AG, Basel.

引用

页码：161 / 164

页数：4

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