Molecular regulatory mechanism of tooth root development

被引：89

作者：

Huang, Xiao-Feng ^{[1
]}

Chai, Yang ^{[2
]}

机构：

[1] Capital Med Univ, Dept Stomatol, Beijing Friendship Hosp, Beijing 100050, Peoples R China

[2] Univ So Calif, CCMB, Ostrow Sch Dent, Los Angeles, CA 90033 USA

来源：

INTERNATIONAL JOURNAL OF ORAL SCIENCE | 2012年 / 4卷 / 04期

基金：

中国国家自然科学基金; 北京市自然科学基金;

关键词：

Hertwig's epithelial root sheath; periodontium; root development; tooth development; BONE MORPHOGENETIC PROTEINS; STEM-CELL COMPARTMENT; NEURAL CREST CELLS; TGF-BETA; TRANSFORMING GROWTH-FACTOR-BETA-1; ODONTOBLAST DIFFERENTIATION; PERIODONTAL-LIGAMENT; ATTACHMENT PROTEIN; EPITHELIAL-CELLS; SMAD PROTEINS;

D O I：

10.1038/ijos.2012.61

中图分类号：

R78 [口腔科学];

学科分类号：

100302 [口腔临床医学];

摘要：

The root is crucial for the physiological function of the tooth, and a healthy root allows an artificial crown to function as required clinically. Tooth crown development has been studied intensively during the last few decades, but root development remains not well understood. Here we review the root development processes, including cell fate determination, induction of odontoblast and cementoblast differentiation, interaction of root epithelium and mesenchyme, and other molecular mechanisms. This review summarizes our current understanding of the signaling cascades and mechanisms involved in root development. It also sets the stage for de novo tooth regeneration. International Journal of Oral Science (2012) 4, 177-181; doi:10.1038/ijos.2012.61; published online 7 December 2012

引用

页码：177 / 181

页数：5

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