Regulatory T cells in health and disease

被引:122
作者
Piccirillo, Ciriaco A. [1 ]
机构
[1] McGill Univ, Dept Microbiol & Immunol, Canada Res Chair, Ctr Study Host Resistance, Montreal, PQ H3A 2B4, Canada
关键词
CD4(+)CD25(+) regulatory T cells; Foxp3; Tolerance; Suppression;
D O I
10.1016/j.cyto.2008.07.469
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 [生物化学与分子生物学]; 081704 [应用化学];
摘要
Regulatory T (Treg) cells have emerged as a central control point in the modulation of various immune responses, including autoimmune responses and immunity to transplants, allergens, tumors, and infectious microbes. The immune system has evolved complex processes to ensure tolerance to autoantigens while preserving the potential to mount and maintain life-long humoral and cellular immune responses against invading pathogens. In this review, we summarize research showing that naturally occurring (nTreg) and induced Treg (iTreg) cell subsets, and in particular CD4(+)Foxp3(+) Treg cells, are critical in the control of immune responses in rodents and humans. We also discuss the cellular and molecular factors that affect CD4(+)Foxp3(+) Treg cell development, homeostasis, and function and consequential immunity to selfand non-self antigens. Recent studies have shed light in our understanding of the development of novel methods of autoimmune disease prevention and treatment via enhancing and re-establishing Treg-mediated dominant control over self-reactive T cells in animal models and humans. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码:395 / 401
页数:7
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