Mode of antibacterial action of totarol, a diterpene from Podocarpus nagi

被引：62

作者：

Haraguchi, H ^{[1
]}

Oike, S ^{[1
]}

Muroi, H ^{[1
]}

Kubo, I ^{[1
]}

机构：

[1] UNIV CALIF BERKELEY, DEPT ENVIRONM SCI POLICY & MANAGEMENT, BERKELEY, CA 94720 USA

来源：

PLANTA MEDICA | 1996年 / 62卷 / 02期

关键词：

Podocarpus nagi; Podocarpaceae; totarol; antimicrobial action; respiratory inhibition; electron transport; Pseudomonas aeruginosa;

D O I：

10.1055/s-2006-957832

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The antimicrobial mechanism of totarol was studied using Pseudomonas aeruginosa IFO 3080. This diterpene inhibited oxygen consumption and respiratory-driven proton translocation in whole cells, and oxidation of NADH in membrane preparation. NADH-cytochrome c reductase was inhibited by totarol while cytochrome c oxidase was not. NADH-DPIP reductase and NADH-CoQ reductase were also inhibited. The site of respiratory inhibition of totarol was thought to be near CoQ in the bacterial electron transport chain.

引用

页码：122 / 125

页数：4

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