Modulation of the cellular immune system by intravenous immunoglobulin

被引：179

作者：

Tha-In, Thanyalak ^{[1
]}

Bayry, Jagadeesh ^{[2
,3
,4
]}

Metselaar, Herold J. ^{[1
]}

Kaveri, Srini V. ^{[2
,3
,4
]}

Kwekkeboom, Jaap ^{[1
]}

机构：

[1] Erasmus MC, Dept Gastroenterol & Hepatol, NL-3015 CE Rotterdam, Netherlands

[2] Univ Paris 06, Ctr Rech Cordeliers, UMR S 872, F-75006 Paris, France

[3] Univ Paris 05, UMR S 872, Ecole Med Paris, F-75006 Paris, France

[4] Ecole Med Paris, U 872, INSERM, F-75006 Paris, France

来源：

TRENDS IN IMMUNOLOGY | 2008年 / 29卷 / 12期

关键词：

D O I：

10.1016/j.it.2008.08.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Intravenous immunoglobulin (IVIg) is therapeutically used in a variety of immune-mediated diseases. The beneficial effects of Wig in auto-antibody-mediated diseases can be explained by neutralization, accelerated clearance and prevention of Fc gamma-receptor binding of auto-antibodies. However, the means by which Wig exerts therapeutic effects in disorders mediated by cellular immunity have remained enigmatic. Clinical improvements, followed by IVIg treatment, often extend beyond the half-life of infused IgG, thereby indicating that IVIg modifies the cellular immune compartment for a prolonged period. Here, we discuss recent advances in the understanding of different, mutually non-exclusive mechanisms of action of Wig on cells of the innate and adaptive immune system. These mechanisms might explain the beneficial effects of IVIg in certain autoimmune and inflammatory diseases.

引用

页码：608 / 615

页数：8

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