Mapping of rat Chromosome 2 markers generated from chromosome-sorted DNA

被引：20

作者：

Deng, AY

Jackson, CM

Hoebee, B

Rapp, JP

机构：

[1] MED COLL OHIO,DEPT MED,TOLEDO,OH 43699

[2] NATL INST PUBL HLTH & ENVIRONM PROTECT,HLTH EFFECTS RES LAB,NL-3720 RA BILTHOVEN,NETHERLANDS

来源：

MAMMALIAN GENOME | 1997年 / 8卷 / 10期

关键词：

D O I：

10.1007/s003359900555

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A quantitative trait locus (QTL) for blood pressure has recently been mapped to a region of roughly 30 cM on rat Chromosome (Chr) 2 by linkage and by the use of congenic strains. For further fine mapping of the QTL, however, closely linked chromosome markers residing in this 30-cM region are required. In the current work, 36 new markers were generated by screening rat Chr 2-sorted DNA libraries and subsequently mapped using five F-2 populations. Combining new and existing markers, the marker density for the 30-cM region approaches, on average, one marker per 1.1 cM.

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收藏

页码：731 / 735

页数：5

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