Erythrocyte and plasma levels of glutamate and aspartate in children affected by migraine

被引：19

作者：

DEufemia, P ^{[1
]}

Finocchiaro, R ^{[1
]}

Lendvai, D ^{[1
]}

Celli, M ^{[1
]}

Viozzi, L ^{[1
]}

Troiani, P ^{[1
]}

Turri, E ^{[1
]}

Giardini, O ^{[1
]}

机构：

[1] UNIV ROMA LA SAPIENZA,DEPT PEDIAT,ROME,ITALY

来源：

CEPHALALGIA | 1997年 / 17卷 / 06期

关键词：

aspartate; cortical spreading depression; glutamate; migraine;

D O I：

10.1046/j.1468-2982.1997.1706652.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In this study we determined plasma and erythrocyte amino acids in children affected by migraine, in order to evaluate glutamate and aspartate metabolism in the pathogenesis of this disorder. Fifteen children with migraine with aura (mean age+/-SD=10.3+/-1.56), 19 children with migraine without aura (mean age+/-SD=10.4+/-1.48) and 16 healthy normal controls (mean age+/-SD 10.6+/-1.53) were investigated. In both migraine groups there were significantly lower plasma glutamate and aspartate levels and significantly higher erythrocyte/plasma concentration (E/P) ratios of these amino acids with respect to the controls. Erythrocyte aspartate concentrations were significantly elevated in migraine children compared to the controls, while erythrocyte glutamate concentrations showed no significant differences between groups. Similar results were observed in both migraine groups. These results seem to suggest the presence of a higher activity of the erythrocytes' glutamate/aspartate transport system that could reflect a similar alteration at the neuronal/glial cell level in the CNS. Our study suggests an imbalance of the excitatory amino acid turnover in the pathogenesis of migraine in children.

引用

页码：652 / 657

页数：6

共 14 条

[1] PLATELET AND PLASMA-LEVELS OF GLUTAMATE AND GLUTAMINE IN MIGRAINE WITH AND WITHOUT AURA [J].