A simple and efficient synthesis of the ras farnesyl-protein transferase inhibitor chaetomellic acid A

被引：24

作者：

Argade, NP ^{[1
]}

Naik, RH ^{[1
]}

机构：

[1] NATL CHEM LAB,DIV ORGAN CHEM SYNTH,PUNE 411008,MAHARASHTRA,INDIA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1996年 / 4卷 / 06期

关键词：

D O I：

10.1016/0968-0896(96)00076-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A simple and efficient synthesis of the ras farnesyl-protein transferase inhibitor chaetomellic acid A anhydride (1) is reported. The imidazopyridinium bromide 5 obtained from the reaction of 2-bromopalmioyl chloride and 2-aminopyridine was reacted with maleic anhydride in the presence of NaOAc/AcOH to form 1 in 62% overall yield in three steps. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：881 / 883

页数：3

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