DNA pooling as a tool for large-scale association studies in complex traits

被引：63

作者：

Norton, N ^{[1
]}

Williams, NM ^{[1
]}

O'Donovan, MC ^{[1
]}

Owen, MJ ^{[1
]}

机构：

[1] Cardiff Univ, Dept Psychol Med, Cardiff CF14 4XN, S Glam, Wales

来源：

ANNALS OF MEDICINE | 2004年 / 36卷 / 02期

关键词：

association; complex traits; DNA pooling; SNP;

D O I：

10.1080/07853890310021724

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pooled genotyping is a powerful and efficient tool for high throughput association analysis, both case-control and family-based. The use of pooling designs can significantly reduce the consumable and labour costs of a study. At the same time, since it is also extremely efficient with DNA resources, pooling can be an extremely effective method for conserving DNA. Here, we consider the main points in study design, and illustrate the application of pooling using psychiatric phenotypes as an example.

引用

页码：146 / 152

页数：7

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