Early Mammary Development: Growth Hormone and IGF-1

被引：78

作者：

Kleinberg, David L. ^{[1
,2
]}

机构：

[1] NYU, Med Ctr, Dept Med, New York, NY 10016 USA

[2] Dept Vet Affairs Med Ctr, New York, NY 10016 USA

来源：

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA | 1997年 / 2卷 / 01期

关键词：

Pleuropotent stem cells; pubertal mammary development; terminal end bud; lactogenesis;

D O I：

10.1023/A:1026373513521

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The first step in pubertal mammary development is the appearance of terminal end buds arising from pleuropotent stem cells present in the immature ductal tree of the prepubertal animal. Work from this laboratory indicates that growth hormone is the pituitary hormone responsible for terminal end bud development. Growth hormone likely acts through the production of IGF-1.(3) This minireview focuses on the hormonal control of early mammary development with special emphasis on the roles of growth hormone and IGF-1.

引用

页码：49 / 57

页数：9

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