Gender and stress: Differential psychophysiological reactivity to stress reexposure in the laboratory

Research has shown that women are more prone to the development of depression and anxiety disorders throughout their lifetimes. Stress reactivity and adaptation to repeated stressors have been linked to depression and anxiety, but studies examining gender differences in psychophysiological responses to repeated stressors are very limited. This study examined gender differences in response to initial and repeated exposure to a laboratory stressor as well as potential mechanisms for these differences. Participants viewed a Holocaust video on two occasions with a 2-day interval between sessions. Self reported negative affect and cardiovascular reactivity were recorded at both sessions. Although gender differences were not found following initial exposure, women exhibited significantly greater heart rate (HR) and negative affect (NA) reactivity to the second exposure as compared to men. Women also reported significantly greater intrusive thoughts and avoidance after the first exposure than men, but these were not found to be significant mediators. The findings indicate that women may be more vulnerable to repeated stress exposures compared to men suggesting sensitization. The implications of our findings and suggestions for future research are discussed. (c) 2008 Elsevier B.V. All rights reserved.