Nucleotide variation along the Drosophila melanogaster fourth chromosome

被引:65
作者
Wang, W
Thornton, K
Berry, A
Long, MY
机构
[1] Univ Chicago, Dept Ecol & Evolut, Chicago, IL 60637 USA
[2] Univ Chicago, Comm Genet, Chicago, IL 60637 USA
[3] Harvard Univ, Museum Comparat Zool, Cambridge, MA 02138 USA
关键词
D O I
10.1126/science.1064521
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The Drosophila melanogaster fourth chromosome, believed to be nonrecombining and invariable, is a classic example of the effect of natural selection in eliminating genetic variation in linked loci. However, in a chromosome-wide assay of nucleotide variation in natural populations, we have observed a high level of polymorphism in a similar to 200-kilobase region and marked levels of polymorphism in several other fragments interspersed with regions of little variation, suggesting different evolutionary histories in different chromosomal domains. Statistical tests of neutral evolution showed that a few haplotypes predominate in the 200-kilobase polymorphic region. Finally, contrary to the expectation of no recombination, we identified six recombination events within the chromosome. Thus, positive Darwinian selection and recombination have affected the evolution of this chromosome.
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页码:134 / 137
页数:4
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