Fibrin Ring Granulomas in Checkpoint Inhibitor-induced Hepatitis

被引：60

作者：

Everett, Jamie ^{[1
]}

Srivastava, Amitabh ^{[2
]}

Misdraji, Joseph ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, James Homer Wright Pathol Labs, Boston, MA 02114 USA

[2] Harvard Med Sch, Brigham & Womens Hosp, Dept Pathol, Boston, MA USA

来源：

AMERICAN JOURNAL OF SURGICAL PATHOLOGY | 2017年 / 41卷 / 01期

关键词：

ipilimumab; nivolumab; immune checkpoint inhibitor; fibrin ring granuloma; hepatitis; liver biopsy; Q-FEVER; IPILIMUMAB; LIVER; INFECTION; PATHOLOGY;

D O I：

10.1097/PAS.0000000000000759

中图分类号：

R36 [病理学];

学科分类号：

100103 [病原生物学];

摘要：

Fibrin ring granulomas are an uncommon finding in liver biopsies although they have been described in liver injury secondary to several infectious and noninfectious entities, most notably Q fever. Immune checkpoint inhibitors are recent advances in cancer therapy, and stimulate the immune system to cause antitumoral effects but may also lead to adverse immune events such as hepatitis and colitis. We report 2 patients on combination ipilimumab/nivolumab who developed hepatitis and had fibrin ring granulomas in their liver biopsies.

引用

页码：134 / 137

页数：4

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