Effects of stress on susceptibility and severity of inflammation in adjuvant-induced arthritis

We have utilized the open field and learned helplessness (LH) models of psychological stress to determine whether a differential response to stress can affect the severity of adjuvant-induced arthritis (AA) within a single rat strain,In response to open field stress, the corticosterone response of the low emotivity rats was significantly lower than that of the high emotivity rats, In spite of the differential corticosterone response to stress, no significant difference was found in paw volumes between the AA high and low emotivity groups, In another study, rats were subjected to a learned LH paradigm and separated into two groups based on failed (LH+) or successful (LH-) avoidance. Plasma corticosterone levels in response to avoidable foot shock in the LH- rats were significantly greater than in the LH+ group. Following injection with adjuvant, paw inflammation occurred earlier and was more severe in the LH- rats compared to the LH+ group, These data show that rats with a greater tendency to avoid foot shock have more severe inflammation, despite having a greater corticosterone response to stress, We conclude that an increased corticosterone I response to stress does not affect susceptibility: to or severity! of inflammation in;AA, Indeed, in the LH model a more robust response to stress is associated with increased inflammation and earlier onset of the disease.