Bile Acids Affect the Growth of Human Cholangiocarcinoma via NF-kB Pathway

被引：47

作者：

Dai, Jiaqi ^{[1
]}

Wang, Hongxia ^{[2
]}

Dong, Ying ^{[3
]}

Zhang, Yinxin ^{[1
]}

Wang, Jian ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Renji Hosp, Div Gen Surg, Shanghai 200127, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Shanghai Renji Hosp, Div Oncol, Shanghai 200127, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Med, Shanghai Renji Hosp, Div Endocrinol, Shanghai 200127, Peoples R China

来源：

CANCER INVESTIGATION | 2013年 / 31卷 / 02期

关键词：

Bile Acids; Human Cholangiocarcinoma; NF-kB; IL-6; COX-2; INDUCE CYCLOOXYGENASE-2 EXPRESSION; HUMAN BREAST-CANCER; KAPPA-B; GENE-EXPRESSION; DEOXYCHOLIC-ACID; EPITHELIAL-CELLS; RECEPTOR; INTERLEUKIN-6; CHOLANGIOCYTES; ACTIVATION;

D O I：

10.3109/07357907.2012.762781

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We observed that free bile acids (CA, DCA, and CDCA) inhibited the growth of cholangiocarcinoma cells by promoting cell apoptosis, while the conjugated bile acids (GCA, GDCA, and GCDCA) stimulated cell growth. Consistently, we found that GDCA stimulated tumor growth and CDCA decreased tumor growth in xenografted mice. Further, the phosphorylated IkB was downregulated by free bile acids, and was upregulated by the conjugated bile acids. IL-6 and COX-2 were decreased by the free bile acids and increased by the conjugated bile acids. Collectively, these results suggest that the bile acids regulate the growth of cholangiocarcinoma by modulating NF-kB pathway.

引用

页码：111 / 120

页数：10

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