Effects of active immunization with a pneumococcal surface protein (PspA) and of locally applied antibodies in experimental otitis media

被引：22

作者：

White, P ^{[1
]}

Hermansson, A ^{[1
]}

Svanborg, C ^{[1
]}

Briles, D ^{[1
]}

Prellner, K ^{[1
]}

机构：

[1] Univ Lund Hosp, Dept Otolaryngol Head & Neck Surg, S-22185 Lund, Sweden

来源：

ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES | 1999年 / 61卷 / 04期

关键词：

otitis media; pneumococcal surface protein A; antibodies;

D O I：

10.1159/000027672

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

An experimental rat model for Streptococcus pneumoniae otitis media was used to investigate passive protection by anti-type 3 capsular antibodies and effects of immunization with pneumococcal surface protein A (PspA). Anti-type 3 antibodies instilled into the middle ear reduced purulent otitis media as compared to control animals (p = 0.015), Secondly, after immunization with PspA, the right middle ear was inoculated with S. pneumoniae type 6A in a dose calibrated to induce purulent otitis media. There was an anti-PspA antibody response in all rats immunized and a reduction in sig ns of purulent otitis media as compared to control animals (p = 0.026). Thus, purulent (acute) otitis media can be reduced by local application of antibodies in the middle ear and also by immunization with a non-type-specific pneumococcal protein, PspA.

引用

页码：206 / 211

页数：6

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