The fimbria-fornix cingular bundle pathways: A review of neurochemical and behavioural approaches using lesions and transplantation techniques

被引:104
作者
Cassel, JC
Duconseille, E
Jeltsch, H
Will, B
机构
[1] LN2C, URA 1939 du CNRS, Université Louis Pasteur, F-67000 Strasbourg, 12, rue Goethe
关键词
D O I
10.1016/S0301-0082(97)00009-9
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Extensive lesions of the fimbria-fornix pathways and the cingular bundle deprive the hippocampus of a substantial part of its cholinergic, noradrenergic and serotonergic afferents and, among several other behavioural alterations, induce lasting impairment of spatial learning and memory capabilities. After a brief presentation of the neuroanatomical organization of the hippocampus and the connections relevant to the topic of this article, studies which have contributed to characterize the neurochemical and behavioural aspects of the fimbria-fornix lesion ''syndrome'' with lesion techniques differing by the extent, the location or the specificity of the damage produced, are reviewed. Furthermore, several compensatory changes that may occur as a reaction to hippocampal denervation (sprouting, changes in receptor sensitivity and modifications of neurotransmitter turnover in spared fibres) are described and discussed in relation with their capacity (or incapacity) to foster recovery from the lesion-induced deficits. According to this background, experiments using intrahippocampal or ''parahippocampal'' grafts to substitute for missing cholinergic, noradrenergic or serotonergic afferents are considered according to whether the reported findings concern neurochemical and/or behavioural effects. Taken together, these experiments suggest that appropriately chosen fetal neurons (or other cells such as, for instance, genetically-modified fibroblasts) implanted into or close to the denervated hippocampus may substitute, at least partially, for missing hippocampal afferents with a neurochemical specificity that closely depends on the neurochemical identity of the grafted neurons. Thereby, such grafts are able not only to restore some functions as they can be detected locally, namely within the hippocampus, but also to attenuate some of the behavioural (and other types of) disturbances resulting from the lesions. In some respects, also these graft-induced behavioural effects might be considered as occurring with a neurochemically-defined specificity. Nevertheless, if a graft-induced recovery of neurochemical markers in the hippocampus seems to be a prerequisite for also behavioural recovery to be observed, this neurochemical recovery is neither the one and only condition for behavioural effects to be expressed, nor is it the one and only mechanism to account for the latter effects. (C) 1997 Elsevier Science Ltd.
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页码:663 / 716
页数:54
相关论文
共 464 条
  • [1] EFFECTS OF NEFIRACETAM ON DEFICITS IN ACTIVE-AVOIDANCE RESPONSE AND HIPPOCAMPAL CHOLINERGIC AND MONOAMINERGIC DYSFUNCTIONS INDUCED BY AF64A IN MICE
    ABE, E
    MURAI, S
    SAITO, H
    MASUDA, Y
    TAKASU, Y
    SHIOTANI, T
    TACHIZAWA, H
    ITOH, T
    [J]. JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION, 1994, 95 (03) : 179 - 193
  • [2] EFFECTS OF SEROTONERGIC DENERVATION ON THE DENSITY AND PLASTICITY OF BRAIN MUSCARINIC RECEPTORS IN THE RAT
    ALONSO, R
    SOUBRIE, P
    [J]. SYNAPSE, 1991, 8 (01) : 30 - 37
  • [3] ENHANCED SPATIAL DISCRIMINATION-LEARNING IN RATS FOLLOWING 5,7-DHT-INDUCED SEROTONERGIC DEAFFERENTATION OF THE HIPPOCAMPUS
    ALTMAN, HJ
    NORMILE, HJ
    GALLOWAY, MP
    RAMIREZ, A
    AZMITIA, EC
    [J]. BRAIN RESEARCH, 1990, 518 (1-2) : 61 - 66
  • [4] IMMUNOCYTOCHEMICAL LOCALIZATION OF SEROTONIN IN THE RAT DENTATE GYRUS FOLLOWING RAPHE TRANSPLANTS
    ANDERSON, KJ
    HOLETS, VR
    MAZUR, PC
    LASHER, RS
    COTMAN, CW
    [J]. BRAIN RESEARCH, 1986, 369 (1-2) : 21 - 28
  • [5] EFFECTS OF CHRONIC BASIC FIBROBLAST GROWTH-FACTOR ADMINISTRATION TO RATS WITH PARTIAL FIMBRIAL TRANSECTIONS ON PRESYNAPTIC CHOLINERGIC PARAMETERS AND MUSCARINIC RECEPTORS IN THE HIPPOCAMPUS - COMPARISON WITH NERVE GROWTH-FACTOR
    ARAUJO, DM
    LAPCHAK, PA
    HEFTI, F
    [J]. JOURNAL OF NEUROCHEMISTRY, 1993, 61 (03) : 899 - 910
  • [6] T-MAZE LEARNING, SPONTANEOUS ACTIVITY AND FOOD-INTAKE RECOVERY FOLLOWING SYSTEMIC ADMINISTRATION OF THE NORADRENALINE NEUROTOXIN, DSP4
    ARCHER, T
    MOHAMMED, AK
    ROSS, SB
    SODERBERG, U
    [J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1983, 19 (01) : 121 - 130
  • [7] ARCHER T, 1982, SCAND J PSYCHOL, P61
  • [8] CHOLINERGIC SYSTEM AND MEMORY IN THE RAT - EFFECTS OF CHRONIC ETHANOL, EMBRYONIC BASAL FOREBRAIN BRAIN TRANSPLANTS AND EXCITOTOXIC LESIONS OF CHOLINERGIC BASAL FOREBRAIN PROJECTION SYSTEM
    ARENDT, T
    ALLEN, Y
    MARCHBANKS, RM
    SCHUGENS, MM
    SINDEN, J
    LANTOS, PL
    GRAY, JA
    [J]. NEUROSCIENCE, 1989, 33 (03) : 435 - 462
  • [9] ELECTROLYTIC, BUT NOT 5,7-DIHYDROXYTRYPTAMINE, LESIONS OF THE NUCLEUS MEDIANUS RAPHE IMPAIR ACQUISITION OF A RADIAL MAZE TASK
    ASIN, KE
    WIRTSHAFTER, D
    FIBIGER, HC
    [J]. BEHAVIORAL AND NEURAL BIOLOGY, 1985, 44 (03): : 415 - 424
  • [10] COMPARATIVE ALTERATIONS OF NICOTINIC AND MUSCARINIC BINDING-SITES IN ALZHEIMERS AND PARKINSONS DISEASES
    AUBERT, I
    ARAUJO, DM
    CECYRE, D
    ROBITAILLE, Y
    GAUTHIER, S
    QUIRION, R
    [J]. JOURNAL OF NEUROCHEMISTRY, 1992, 58 (02) : 529 - 541