Cardioprotection by adiponectin

被引：264

作者：

Ouchi, Noriyuki ^{[1
]}

Shibata, Rei ^{[1
]}

Walsh, Kenneth ^{[1
]}

机构：

[1] Boston Univ, Sch Med, Mol Cardiol Whitaker Cardiovasc Inst, Boston, MA 02118 USA

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2006年 / 16卷 / 05期

关键词：

D O I：

10.1016/j.tcm.2006.03.001

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Obesity-related disorders are closely associated with the pathogenesis of cardiovascular disease. Adiponectin is a circulating adipose tissue-derived hormone that is down-regulated in obese individuals. Hypoadiponectinemia has been identified as an independent risk factor for type 2 diabetes, coronary artery disease, and hypertension, and experimental studies show that adiponectin plays a protective role in the development of insulin resistance, atherosclerosis, and inflammation. More recent findings have shown that adiponectin directly affects signaling in myocardial cells and exerts beneficial actions on the heart after pressure overload and ischemia-reperfusion injury. This review focuses on the role of adiponectin in the regulation of myocardial remodeling and acute cardiac injury.

引用

页码：141 / 146

页数：6

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