Synthesis of a novel structural triblock copolymer of poly(γ-benzyl-L-glutamic acid)-b-poly(ethylene oxide)-b-poly(ε-caprolactone)

被引：53

作者：

Deng, MX ^{[1
]}

Wang, R ^{[1
]}

Rong, GZ ^{[1
]}

Sun, JR ^{[1
]}

Zhang, XF ^{[1
]}

Chen, XS ^{[1
]}

Jing, XB ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China

来源：

BIOMATERIALS | 2004年 / 25卷 / 17期

基金：

中国国家自然科学基金;

关键词：

biodegradation; poly(epsilon-caprolactone); poly(ethylene oxide); poly(gamma-benzyl-L-glutamic acid); triblock copolymer;

D O I：

10.1016/j.biomaterials.2003.10.018

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A novel structural triblock copolymer of poly(gamma-benzyl-L-glutamic acid)-b-poly(ethylene oxide)-b-poly(epsilon-caprolactone) (PBLG-PEO-PCL) was synthesized by a new approach in the following three steps: (1) sequential anionic ring opening polymerization (ROP) of ethylene oxide and epsilon-caprolactone with an acetonitrile/potassium naphthalene initiator system to obtain a diblock copolymer CN-PEO-PCL with a cyano end-group; (2) conversion of the CN end-group into NH2 end-group by hydrogenation to obtain NH2-PEO-PCL; (3) ROP of gamma-benzyl-L-glutamate-N-carboxyanhydrides (Bz-L-GluNCA) with NH2-PEO-PCL as macroinitiator to obtain the target triblock copolymer. The structures from CN-PEO precursor to the triblock copolymers were confirmed by FT-IR and H-1 NMR spectroscopy, and their molecular weights were measured by gel permeation chromatography. The monomer of Bz-L-GluNCA can react almost quantitatively with the amino end-groups of NH2-PEO-PCL macroinitiator by ROP. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：3553 / 3558

页数：6

共 22 条

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