Dysregulation of apoptosis genes in hematopoietic malignancies

被引：132

作者：

Kitada, S ^{[1
]}

Pedersen, IM ^{[1
]}

Schimmer, AD ^{[1
]}

Reed, JC ^{[1
]}

机构：

[1] Burnham Inst, La Jolla, CA 92037 USA

来源：

ONCOGENE | 2002年 / 21卷 / 21期

基金：

加拿大健康研究院;

关键词：

apoptosis; programmed cell death; malignancy;

D O I：

10.1038/sj.onc.1205327

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ever since the discovery of Bel-2 and the elucidation of its role in apoptosis, tremendous interest has arisen in prospects for triggering suicide of malignant cells by exploiting knowledge emerging from apoptosis research. In this review, we summarize information about the multiple genetic lesions which have been identified in apoptosis-regulatory genes of hematopoietic and lymphoid neoplasms. Emerging data about the structural and biochemical details of apoptosis proteins and their upstream regulators have reveal novel strategies for therapeutic intervention, some of which are under interrogation in clinical trials currently.

引用

页码：3459 / 3474

页数：16

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