Circulatory microRNA-145 expression is increased in cerebral ischemia

被引：84

作者：

Gan, C. S. ^{[1
]}

Wang, C. W. ^{[1
]}

Tan, K. S. ^{[2
]}

机构：

[1] Univ Malaya, Fac Med, Dept Mol Med, Kuala Lumpur, Malaysia

[2] Univ Malaya, Fac Med, Dept Med, Kuala Lumpur, Malaysia

来源：

GENETICS AND MOLECULAR RESEARCH | 2012年 / 11卷 / 01期

关键词：

Biomarker; Circulation; Gene expression; Ischemic stroke; MicroRNA-145; Postnatal neovascularization; SMOOTH; BLOOD;

D O I：

10.4238/2012.January.27.1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cerebral ischemia or ischemic stroke is mainly attributed to vascular and circulation disorders. Among protein biomarkers, RNA profiles have also been identified as markers of ischemic stroke. MicroRNA-145 expression is ostensibly recognized as marker and modulator of vascular smooth muscle cell phenotype; however, expression levels in ischemic stroke had not been investigated. Employing real-time quantitative PCR, we examined the expression profile of circulatory microRNA-145 in healthy control subjects (N = 14) and ischemic stroke patients (N = 32). Circulatory microRNA-145 expression was significantly higher in ischemic stroke patients than in control subjects. This demonstrates that hemostatic mechanisms are affected by ischemic stroke. We conclude that circulating microRNA-145 has potential as a biomarker for ischemic stroke.

引用

页码：147 / 152

页数：6

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