Circulating Zonulin, a Marker of Intestinal Permeability, Is Increased in Association with Obesity-Associated Insulin Resistance

被引:224
作者
Maria Moreno-Navarrete, Jose [1 ]
Sabater, Monica
Ortega, Francisco
Ricart, Wifredo
Manuel Fernandez-Real, Jose
机构
[1] CIBEROBN CB06 03 010, IdIBGi, Dept Diabet Endocrinol & Nutr, Girona, Spain
来源
PLOS ONE | 2012年 / 7卷 / 05期
关键词
DIET-INDUCED OBESITY; TIGHT JUNCTIONS; GUT MICROBIOTA; MICE; PATHOGENESIS; INFLAMMATION; MODULATOR; DISEASE;
D O I
10.1371/journal.pone.0037160
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Zonulin is the only physiological mediator known to regulate intestinal permeability reversibly by modulating intercellular tight junctions. To investigate the relationship between intestinal permeability and obesity-associated metabolic disturbances in humans, we aimed to study circulating zonulin according to obesity and insulin resistance. Circulating zonulin (ELISA) was measured in 123 caucasian men in association with inflammatory and metabolic parameters ( including minimal model-measured insulin sensitivity). Circulating zonulin increased with body mass index (BMI), waist to hip ratio (WHR), fasting insulin, fasting triglycerides, uric acid and IL-6, and negatively correlated with HDL-cholesterol and insulin sensitivity. In multiple regression analysis, insulin sensitivity (p = 0.002) contributed independently to circulating zonulin variance, after controlling for the effects of BMI, fasting triglycerides and age. When circulating IL-6 was added to this model, only BMI (p = 0.01) contributed independently to circulating zonulin variance. In conclusion, the relationship between insulin sensitivity and circulating zonulin might be mediated through the obesity-related circulating IL-6 increase.
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页数:5
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