A Role for Th17 Cells in the Immunopathogenesis of Atopic Dermatitis?

被引：105

作者：

Di Cesare, Antonella ^{[1
,2
,3
]}

Di Meglio, Paola ^{[1
,2
]}

Nestle, Frank O. ^{[1
,2
]}

机构：

[1] Kings Coll London, Sch Med, St Johns Inst Dermatol, London SE1 9RT, England

[2] NIHR Biomed Res Ctr, London, England

[3] Univ Aquila, Dept Dermatol, I-67100 Laquila, Italy

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2008年 / 128卷 / 11期

关键词：

D O I：

10.1038/jid.2008.283

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Atopic dermatitis (AD) is a common inflammatory skin disease. Both epidermal barrier dysfunction and immunodysregulation are suggested to influence the pathogenesis of AD. AD has been considered a paradigmatic T helper cell (Th) 2-mediated disease, with a switch to a Th1 cell environment during the chronic phase of the disease. Previously unreported findings now suggest a possible role for Th17 cells as well.

引用

页码：2569 / 2571

页数：4

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